ChemicalBook CAS DataBase List Lenalidomide

Lenalidomide synthesis

11synthesis methods

Product Name:Lenalidomide
CAS Number:191732-72-6
Molecular formula:C13H13N3O3
Molecular Weight:259.26

3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione

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Yield:191732-72-6 98.2%

Reaction Conditions:

with palladium-carbon;hydrogen in ethanol at 40; under 3000.3 Torr;Pressure;Temperature;

Steps:

1.2 example 1

2) 0.4 g of 3-(4-nitro-1-oxo-2,3-dihydro-1H-isoindol-2-yl)piperidine-2,6-dioneand 0.4 g of 5% palladium carbon were added to a solution of 15 ml of ethanol Kettle,Into the hydrogen (hydrogen pressure of 0.4MPa)In 40, ° C reduction reaction, the reaction was completed, filtered, the filtrate was concentrated under reduced pressure,Recrystallization of petroleum ether gave lenalidomide 21.6 g, yield 98.2%, HPLC purity 99.20%.

References:

CN107337666,2017,A Location in patent:Paragraph 0025; 0030; 0033-0034; 0037-0038; 0041-0042; 0045