Losartan Carboxaldehyde synthesis
- Product Name:Losartan Carboxaldehyde
- CAS Number:114798-36-6
- Molecular formula:C22H21ClN6O
- Molecular Weight:420.89
114798-26-4
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114798-36-6
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Yield:114798-36-6 94%
Reaction Conditions:
with dipyridinium dichromate in N,N-dimethyl-formamide at 20 - 50; for 6 h;Alkaline conditions;
Steps:
2.2 (2) 5-aldehyde losartan
317g of losartan (0.75mol) was dissolved in DMF (1000mL) and was added in portions with stirring 418.5g of PDC. Temperature was not to exceed 50°C. After addition of PDC was complete, it was stirred at room temperature for 6 hours. The reaction solution was poured into 5000g of water. The solution was extracted three times with ethyl acetate (2500mL × 3). The combined organic phases was washed saturated brine (2500mL) then dried over anhydrous magnesium sulfate. it was filtered and concentrated to give 296g of a solid 5-aldehyde losartan, yield 94%
References:
CN105218527,2016,A Location in patent:Paragraph 0015
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124750-67-0
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114798-36-6
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114798-36-6
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114798-36-6
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114798-36-6
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