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Losartan potassium

Description References
Losartan potassium
Losartan potassium structure
CAS No.
124750-99-8
Chemical Name:
Losartan potassium
Synonyms
MK-95;COZAAR;MK 954;DUP 753;mk-0954;Aradois;l-158086;dupont753;thanolpotassium;DuP-753 potassium
CBNumber:
CB1442564
Molecular Formula:
C22H23ClKN6O
Formula Weight:
462.01
MOL File:
124750-99-8.mol

Losartan potassium Properties

Melting point:
263-265°C
storage temp. 
Desiccate at RT
solubility 
Freely soluble in water and in methanol, slightly soluble in acetonitrile.
form 
powder or crystals
Merck 
14,5583
BRN 
5845770
InChIKey
OXCMYAYHXIHQOA-UHFFFAOYSA-N
CAS DataBase Reference
124750-99-8(CAS DataBase Reference)
FDA UNII
3ST302B24A
NCI Dictionary of Cancer Terms
Cozaar; losartan potassium
SAFETY
  • Risk and Safety Statements
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36/37/39
WGK Germany  3
RTECS  NI6755100
HS Code  2933290000

Losartan potassium price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 61188 Losartan potassium analytical standard 124750-99-8 100mg $161 2019-12-02 Buy
Sigma-Aldrich 1370462 Losartan potassium United States Pharmacopeia (USP) Reference Standard 124750-99-8 150mg $352.8 2019-12-02 Buy
TCI Chemical L0232 Losartan Potassium >98.0%(HPLC)(T) 124750-99-8 5g $120 2020-06-24 Buy
TCI Chemical L0232 Losartan Potassium >98.0%(HPLC)(T) 124750-99-8 25g $420 2020-06-24 Buy
Cayman Chemical 10006594 Losartan (potassium salt) ≥98% 124750-99-8 10mg $12 2020-06-24 Buy

Losartan potassium Chemical Properties,Uses,Production

Description

As a angiotensin II receptor antagonist, Losartan Potassium is the potassium salt of losartan with antihypertensive activity, which is mainly used in the therapy of high blood pressure (hypertension) and diabetic nephropathy. It functions by relaxing blood vessels so that blood can flow more easily. It is also effective to help protect the kidneys from damage caused by diabetes and lower the risks of stroke in patients suffering from hypertension and myocardial enlargement. Besides, recent study has suggested that losartan is beneficial to reverse age related dysfunction in maintaining normal blood pressure and cellular energy usage on mitochondria and it can probably be used to treat left ventricular hypertrophy. It may also be used as an alternative agent for the treatment of systolic dysfunction, myocardial infarction, coronary artery disease, and heart failure.

References

https://en.wikipedia.org/wiki/Losartan
https://www.drugbank.ca/drugs/DB00678
https://pubchem.ncbi.nlm.nih.gov/compound/11751549#section=Top
http://www.medicinenet.com/losartan-oral/article.htm

Description

Losartan potassium is the first potent and selective non-peptide angiotensin II (AT II) AT1 receptor antagonist introduced to the market as a once-daily oral antihypertensive. It is efficacious and long lasting in controlling blood pressure in spontaneous hypertensive rats, in patients with essential hypertension in addition to those patients with renal impairment. Since losartan functions by competitive antagonism at the level of receptor, which represents the most direct way of selectively inhibiting the renin-angiotensin system (RAS) independent of the source of AT II, its use has been reported to be free of the coughing side effect exhibited by the ACE inhibitors. In contrast to calcium channel blockers, losartan does not appear to cause ankle edema, headache and tachycardia. It is also reported to be in clinical trials for the treatment of heart failure. Other reports indicate that losartan may have potential efficacy as an anxiolytic, an antiglaucoma agent, in addition to in providing protection against stroke and in preventing the myointimal proliferative response of the vascular wall after coronary angioplasty and surgery.

Chemical Properties

White to Off-White Crystalline Powder

Originator

DuPont Merck (U.S.A.)

Uses

A nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.

Uses

antihypertensive, AT1 angiotensin II antagonist

Uses

Coronary vasodilator used in the diagnosis of coronary heart disease (adenosine A2A agonist).

brand name

Cozaar (Merck).

Biological Activity

Selective non-peptide angiotensin AT 1 receptor antagonist. Inhibits the contractile effects of angiotensin II on rabbit aorta and jugular vein (pA 2 = 8.27). Orally active antihypertensive agent.

Losartan potassium Preparation Products And Raw materials

Raw materials

Preparation Products


Losartan potassium Suppliers

Global( 340)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22625 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 568 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24754 60
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 2678 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30043 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23977 58
Accela ChemBio Inc.
(+1)-858-699-3322
(+1)-858-876-1948 info@accelachem.com United States 19988 58
QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409 orders@qcchemical.com United States 8406 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930501651
whatsapp: +8619930501651 breeduan@crovellbio.com CHINA 2581 58

View Lastest Price from Losartan potassium manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-04-15 Losartan potassium Joyce
124750-99-8
US $20.00 / KG 1KG 99% 20tons Hebei Guanlang Biotechnology Co., Ltd.
2020-05-08 Losartan potassium
124750-99-8
US $0.00-0.00 / 公斤 1KG 99.0% 600 MT Shaanxi Dideu Medichem Co. Ltd
2019-10-29 Losartan potassium
124750-99-8
US $0.00 / KG 1g 99.9% 1 ton Hebei shuoxi biotechnology co. LTD

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