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Losartan potassium

Description References
Losartan potassium
Losartan potassium structure
CAS No.
124750-99-8
Chemical Name:
Losartan potassium
Synonyms
MK-95;MK 954;COZAAR;DUP 753;mk-0954;Aradois;l-158086;dupont753;thanolpotassium;LOSARTAN POTASSIUM
CBNumber:
CB1442564
Molecular Formula:
C22H23ClKN6O
Formula Weight:
462.01
MOL File:
124750-99-8.mol

Losartan potassium Properties

Melting point:
263-265°C
storage temp. 
Desiccate at RT
solubility 
Freely soluble in water and in methanol, slightly soluble in acetonitrile.
form 
powder or crystals
Merck 
14,5583
BRN 
5845770
InChIKey
OXCMYAYHXIHQOA-UHFFFAOYSA-N
CAS DataBase Reference
124750-99-8(CAS DataBase Reference)

SAFETY

Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36/37/39
WGK Germany  3
RTECS  NI6755100
Hazardous Substances Data 124750-99-8(Hazardous Substances Data)

Losartan potassium price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 61188 Losartan potassium analytical standard 124750-99-8 100mg $157 2018-11-20 Buy
Sigma-Aldrich 1370462 Losartan potassium United States Pharmacopeia (USP) Reference Standard 124750-99-8 150mg $352.8 2018-11-20 Buy
TCI Chemical L0232 Losartan Potassium >98.0%(HPLC)(T) 124750-99-8 5g $152 2018-11-22 Buy
TCI Chemical L0232 Losartan Potassium >98.0%(HPLC)(T) 124750-99-8 25g $521 2018-11-22 Buy
Cayman Chemical 10006594 Losartan (potassium salt) ≥98% 124750-99-8 10mg $12 2018-11-19 Buy

Losartan potassium Chemical Properties,Uses,Production

Description

As a angiotensin II receptor antagonist, Losartan Potassium is the potassium salt of losartan with antihypertensive activity, which is mainly used in the therapy of high blood pressure (hypertension) and diabetic nephropathy. It functions by relaxing blood vessels so that blood can flow more easily. It is also effective to help protect the kidneys from damage caused by diabetes and lower the risks of stroke in patients suffering from hypertension and myocardial enlargement. Besides, recent study has suggested that losartan is beneficial to reverse age related dysfunction in maintaining normal blood pressure and cellular energy usage on mitochondria and it can probably be used to treat left ventricular hypertrophy. It may also be used as an alternative agent for the treatment of systolic dysfunction, myocardial infarction, coronary artery disease, and heart failure.

References

https://en.wikipedia.org/wiki/Losartan
https://www.drugbank.ca/drugs/DB00678
https://pubchem.ncbi.nlm.nih.gov/compound/11751549#section=Top
http://www.medicinenet.com/losartan-oral/article.htm

Description

Losartan potassium is the first potent and selective non-peptide angiotensin II (AT II) AT1 receptor antagonist introduced to the market as a once-daily oral antihypertensive. It is efficacious and long lasting in controlling blood pressure in spontaneous hypertensive rats, in patients with essential hypertension in addition to those patients with renal impairment. Since losartan functions by competitive antagonism at the level of receptor, which represents the most direct way of selectively inhibiting the renin-angiotensin system (RAS) independent of the source of AT II, its use has been reported to be free of the coughing side effect exhibited by the ACE inhibitors. In contrast to calcium channel blockers, losartan does not appear to cause ankle edema, headache and tachycardia. It is also reported to be in clinical trials for the treatment of heart failure. Other reports indicate that losartan may have potential efficacy as an anxiolytic, an antiglaucoma agent, in addition to in providing protection against stroke and in preventing the myointimal proliferative response of the vascular wall after coronary angioplasty and surgery.

Chemical Properties

White to Off-White Crystalline Powder

Originator

DuPont Merck (U.S.A.)

Uses

A nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.

Uses

antihypertensive, AT1 angiotensin II antagonist

Uses

Coronary vasodilator used in the diagnosis of coronary heart disease (adenosine A2A agonist).

brand name

Cozaar (Merck).

Biological Activity

Selective non-peptide angiotensin AT 1 receptor antagonist. Inhibits the contractile effects of angiotensin II on rabbit aorta and jugular vein (pA 2 = 8.27). Orally active antihypertensive agent.

Losartan potassium Preparation Products And Raw materials

Raw materials

Preparation Products


Losartan potassium Suppliers

Global( 297)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3217 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22043 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20786 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32651 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
02783214688 bruce@xrdchem.cn CHINA 552 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 894 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1662 55
Meihua Biological Technology Co.,Ltd
15175972705
031145896235 sales@hbmeihua.cn CHINA 215 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 24118 58
Accela ChemBio Inc.
(+1)-858-699-3322
(+1)-858-876-1948 info@accelachem.com United States 12156 58

View Lastest Price from Losartan potassium manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-24 Losartan potassium
124750-99-8
US $7.00 / kg 1kg 99% 100kg career henan chemical co
2018-03-15 Losartan potassium 124750-99-8
124750-99-8
US $10.00 / KG 10G 99% 10MT Hubei XinRunde Chemical Co., Ltd.
2018-05-24 Losartan potassium
124750-99-8
US $1.00 / UG 1UG 99.5% 10000000 Meihua Biological Technology Co.,Ltd

124750-99-8(Losartan potassium)Related Search:


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  • Aromatics
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