Methanesulfonic acid 2-fluoroethyl ester synthesis
- Product Name:Methanesulfonic acid 2-fluoroethyl ester
- CAS Number:461-31-4
- Molecular formula:C3H7FO3S
- Molecular Weight:142.15
Yield:461-31-4 90%
Reaction Conditions:
with triethylamine in dichloromethane at 20 - 25; for 16 h;
Steps:
5 synthesis of 2-fluoroethylmethanesulfonate
In the three reaction flask with a stirrer was added 20 g of 2-fluoro-ethanol and 200 ml of dichloromethane (DCM),Then it was added 47.4 g of triethylamine and 39.3 g of methanesulfonyl chloride to the solution, stirred for 16 hours at 20-25 ° until the reactionComplete, water was added to the above-described system, followed by extraction by dichloromethane, the organic phase was washed with water, dried over anhydrous sodium sulfateDry, concentrated under reduced pressure, the crude product by column chromatography on silica gel, petroleum ether / ethyl acetate (v / v = 90: 10) as eluent to give 35.4 g 2-Fluoroethyl - methanesulfonate, yield 90%, HPLC purity 97.8A%
References:
CN105622469,2016,A Location in patent:Paragraph 0023; 0033; 0034
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