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methicillin synthesis

2synthesis methods
Methicillin, [2S-(2α,5α,6β)]-3,3-dimethyl-7-oxo-6-(2,6-dimethoxybenzamido)- 4-thia-1-azabicyclo[3.2.0]-heptan-2-carboxylic acid (32.1.1.3), is synthesized by acylating 6- APA with 2,6-dimethoxybenzoic acid chloride in the presence of triethylamine.

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Yield:-

Steps:

Multi-step reaction with 2 steps
1: CHCl3
2: (i) ClCO2Et, Et3N, CHCl3, dioxane, (ii) /BRN= 1082694/

References:

Glombitza,K.-W. [Justus Liebigs Annalen der Chemie,1964,vol. 673,p. 166 - 170]

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