ChemicalBook CAS DataBase List METHYL 1-METHYLPYRROLE-2-CARBOXYLATE

METHYL 1-METHYLPYRROLE-2-CARBOXYLATE synthesis

13synthesis methods

Product Name:METHYL 1-METHYLPYRROLE-2-CARBOXYLATE
CAS Number:37619-24-2
Molecular formula:C7H9NO2
Molecular Weight:139.15

1193-62-0

74-88-4

37619-24-2

Methyl-1H-pyrrole-2-carboxylate (10 g, 79.9 mmol) was dissolved in anhydrous THF (200 mL) at 0 °C and NaH (3.52 g, 60% w/w, 87.9 mmol) was slowly added. The reaction mixture was stirred at 20 °C for 30 min before CH3I (13.62 g, 95.9 mmol) was added dropwise. The reaction was continued to be stirred at 20 °C for 17 hours. After completion of the reaction, the reaction was quenched by slowly pouring the mixture into aqueous NH4Cl (200 mL). The aqueous phase was extracted with EtOAc (200 mL x 2), the organic layers were combined and washed with brine (150 mL), dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: EtOAc/petroleum ether=1/20) to afford methyl 1-methyl-1H-pyrrole-2-carboxylate (9.88 g, 71 mmol, 89% yield) as a yellow oil. Mass spectrum (EI+, m/z): 140.1 [M+H]+.

67-56-1 Synthesis

67-56-1
789 suppliers
$7.29/5ml-f

6973-60-0
204 suppliers
$6.00/250mg

18107-18-1
209 suppliers
$33.00/5g

37619-24-2
112 suppliers
$10.00/500mg

Yield:-

Reaction Conditions:

at 20; for 1 h;

Steps:

26
To a solution of 1-methyl-2-pyrrolecarboxylic acid (1.03 g, 8.22 mmol) in MeOH (5 mL) and dioxane (5 mL) at room temperature, trimethylsilyldiazomethane (2M in ether, 5.0 mL, 10.0 mmol) was added. After being stirred at room temperature for 1 h, the mixture was concentrated in vacuo to give methyl 1-methyl-2-pyrrolecarboxylate as a volatile oil (1.14 g).

References:

Millennium Pharmaceuticals, Inc. US2007/259924, 2007, A1 Location in patent:Page/Page column 33

1193-62-0 Synthesis

1193-62-0
229 suppliers
$5.00/1g

74-88-4
360 suppliers
$15.00/10g

37619-24-2
112 suppliers
$10.00/500mg

References

6973-60-0
204 suppliers
$6.00/250mg

74-88-4
360 suppliers
$15.00/10g

37619-24-2
112 suppliers
$10.00/500mg

References

1193-62-0 Synthesis