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2928-14-5

Methyl 3-(4-fluorophenyl)propanoate synthesis

9synthesis methods
-

Yield:2928-14-5 3.08 g (16.9 mmol, 95%)

Reaction Conditions:

in acetyl chloride;

Steps:

119.A A.

A. 3-(4-Fluorophenyl)propionic acid, methyl ester To 35 mL of methanol (Burdick and Jackson) cooled in an ice-bath was aded dropwise over several minutes 3.5 mL of acetyl chloride (Mallinckrodt). The solution was stirred for 10 minutes then 3.00 g (17.9 mmol, Trans World Chemicals) of 3-(4-fluorophenyl)propionic acid, was added. The reaction mixture was stirred at 0° C. for 6 hours then concentrated in vacuo. The residue was dissolved in 25 mL of ether, dried (magnesium sulfate) and concentrated in vacuo to give 3.08 g (16.9 mmol, 95%) of title ester as a colorless liquid.

References:

US5100889,1992,A