Methyl 3-(4-fluorophenyl)propanoate synthesis
- Product Name:Methyl 3-(4-fluorophenyl)propanoate
- CAS Number:2928-14-5
- Molecular formula:C10H11FO2
- Molecular Weight:182.19
459-31-4
233 suppliers
$6.00/250mg
2928-14-5
33 suppliers
$82.50/1g
Yield:2928-14-5 3.08 g (16.9 mmol, 95%)
Reaction Conditions:
in acetyl chloride;
Steps:
119.A A.
A. 3-(4-Fluorophenyl)propionic acid, methyl ester To 35 mL of methanol (Burdick and Jackson) cooled in an ice-bath was aded dropwise over several minutes 3.5 mL of acetyl chloride (Mallinckrodt). The solution was stirred for 10 minutes then 3.00 g (17.9 mmol, Trans World Chemicals) of 3-(4-fluorophenyl)propionic acid, was added. The reaction mixture was stirred at 0° C. for 6 hours then concentrated in vacuo. The residue was dissolved in 25 mL of ether, dried (magnesium sulfate) and concentrated in vacuo to give 3.08 g (16.9 mmol, 95%) of title ester as a colorless liquid.
References:
US5100889,1992,A
67-56-1
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405-99-2
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201230-82-2
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50415-71-9
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2928-14-5
33 suppliers
$82.50/1g
67-56-1
776 suppliers
$9.00/25ml
459-31-4
233 suppliers
$6.00/250mg
2928-14-5
33 suppliers
$82.50/1g
459-31-4
233 suppliers
$6.00/250mg
18107-18-1
213 suppliers
$33.00/5g
2928-14-5
33 suppliers
$82.50/1g
459-57-4
603 suppliers
$6.00/25g
2928-14-5
33 suppliers
$82.50/1g