ChemicalBook CAS DataBase List methyl 3-amino-2-fluorobenzoate

methyl 3-amino-2-fluorobenzoate synthesis

10synthesis methods

Product Name:methyl 3-amino-2-fluorobenzoate
CAS Number:1195768-18-3
Molecular formula:C8H8FNO2
Molecular Weight:169.15

67-56-1 Synthesis

67-56-1
727 suppliers
$9.00/25ml

914223-43-1 Synthesis

914223-43-1
145 suppliers
$11.00/250mg

1195768-18-3
210 suppliers
$11.00/100mg

Yield:1195768-18-3 100%

Reaction Conditions:

with thionyl chloride at 0; for 12 h;Reflux;

Steps:

137

Example 1378-Fluoro-3 ,3 -dimethyl-2- (3 -morpholin-4-yl-phenyl) - 1 ,2,3 ,4-tetrahydro-quinoline-7- carboxylic acid To a stirred solution of 3-amino-2-fiuoro-benzoic acid (25 g, 161 mmol) in methanol (300 mL) was added thionyl chloride (30 mL, 403 mmol) dropewise at 0 °C . Then the mixture solution was refluxed for 12 hours before cooling to room temperature. Then the reaction mixture was concentrated in vacuo and the residue was dissolved in ethyl acetate (500 mL), washed with saturated aqueous sodium bicarbonate solution (3 x 100 mL), dried over anhydrous sodium sulfate and concentrated in vacuo to afford 3-amino-2-fiuoro- benzoic acid methyl ester (27.5 g, quant.) as a pale-white solid: LC/MS m/e calcd for C₈H₈FN0₂ (M+H)⁺: 170.16, observed: 169.9.

References:

WO2011/128251,2011,A1 Location in patent:Page/Page column 230-231

946126-94-9 Synthesis