Methyl 3-amino-4-bromobenzoate synthesis
- Product Name:Methyl 3-amino-4-bromobenzoate
- CAS Number:46064-79-3
- Molecular formula:C8H8BrNO2
- Molecular Weight:230.06
67-56-1
2840-29-1
46064-79-3
General method: 3-Amino-4-bromobenzoic acid (1 eq.) was dissolved in methanol and cooled to 0°C. The mixture was then heated to 0°C and refluxed for 24 hours. Thionyl chloride (2.5 eq.) was added slowly and the reaction mixture was heated to reflux for 24 hours after completion of the addition. After completion of the reaction, the solvent was removed by evaporation and the residue was neutralized with saturated aqueous NaHCO3 solution. Subsequently, the mixture was extracted with ethyl acetate, the organic layers were combined and dried with anhydrous magnesium sulfate. Finally, the target product, methyl 3-amino-4-bromobenzoate, was purified by column chromatography (hexane/ethyl acetate as eluent).
6319-40-0
207 suppliers
$10.00/1g
46064-79-3
150 suppliers
$10.00/1g
Yield:-
Steps:
Multi-step reaction with 2 steps
1: sulfuric acid / 4 h / 0 °C / Reflux; Inert atmosphere
2: methanol; sodium dithionite / water / 4 h / Reflux; Inert atmosphere
References:
BEIGENE, LTD.;ZHOU, Changyou;REN, Bo;WANG, Hexiang WO2013/97226, 2013, A1
67-56-1
782 suppliers
$7.29/5ml-f
2840-29-1
165 suppliers
$5.00/250mg
46064-79-3
150 suppliers
$10.00/1g
2363-16-8
166 suppliers
$8.00/1g
46064-79-3
150 suppliers
$10.00/1g
67-56-1
782 suppliers
$7.29/5ml-f
6319-40-0
207 suppliers
$10.00/1g
46064-79-3
150 suppliers
$10.00/1g
4518-10-9
197 suppliers
$12.80/1g
6942-37-6
90 suppliers
$19.00/250mg
46064-79-3
150 suppliers
$10.00/1g
106896-48-4
92 suppliers
$20.00/100mg