Methyl 3-amino-4-hydroxybenzoate synthesis
- Product Name:Methyl 3-amino-4-hydroxybenzoate
- CAS Number:536-25-4
- Molecular formula:C8H9NO3
- Molecular Weight:167.16
67-56-1
776 suppliers
$7.29/5ml-f
1571-72-8
274 suppliers
$8.00/1g
536-25-4
197 suppliers
$11.00/250mg
Yield:536-25-4 100%
Reaction Conditions:
with sulfuric acid for 24 h;Reflux;
Steps:
Step1: preparation of methyl 4-amino-3-nitrobenzoate (12).
General procedure: Toa solution of 4-amino-3-nitrobenzoic acid (11, 500 mg, 2.75 mmol) inMeOH (20 mL), a catalytic amount of concentrated sulfuric acid was added in a dropwisefashion. The mixture was heated at reflux temperature overnight. After beingcooled, the reaction was quenched by saturated NaHCO3solution andextracted by ethyl acetate.The organic layer was separated and dried over anhydroussodium sulfate. Filtration and concentrationin vacuogave 12 (519 mg, 97%); yellow solid
References:
Jaikhan, Pattaporn;Buranrat, Benjaporn;Itoh, Yukihiro;Chotitumnavee, Jiranan;Kurohara, Takashi;Suzuki, Takayoshi [Bioorganic and Medicinal Chemistry Letters,2019,vol. 29,# 10,p. 1173 - 1176] Location in patent:supporting information
99-42-3
188 suppliers
$8.00/5g
536-25-4
197 suppliers
$11.00/250mg
67-56-1
776 suppliers
$7.29/5ml-f
616-82-0
233 suppliers
$10.00/5g
536-25-4
197 suppliers
$11.00/250mg
75-36-5
589 suppliers
$17.92/100G
1571-72-8
274 suppliers
$8.00/1g
536-25-4
197 suppliers
$11.00/250mg
18107-18-1
214 suppliers
$33.00/5g
1571-72-8
274 suppliers
$8.00/1g
536-25-4
197 suppliers
$11.00/250mg