Methyl 3-(diMethylcarbaMoyl)benzoate synthesis
- Product Name:Methyl 3-(diMethylcarbaMoyl)benzoate
- CAS Number:69383-71-7
- Molecular formula:C11H13NO3
- Molecular Weight:207.23
1459-93-4
333 suppliers
$12.60/100g
124-40-3
547 suppliers
$18.00/100ml
69383-71-7
15 suppliers
$45.00/100mg
Yield:69383-71-7 100%
Reaction Conditions:
with benzotriazol-1-ol;1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in tetrahydrofuran;methanol at 20; for 2 h;
Steps:
139.1
Methyl isophthalate (2.00 g, 11.1 mmol) was dissolved in THF (60 mL), and a 2.0 mol/L solution of dimethylamine (11.1 ml, 22.2 mmol) in methanol, EDC hydrochloride (4.27 g, 22.2 mmol) and 1-hydroxybenzotriazole monohydrate (3.40 g, 22.2 mmol) were added thereto, followed by stirring at room temperature for 2 hours. Water was added to the reaction mixture, followed by extraction with ethyl acetate. The organic layer was washed with a saturated aqueous solution of sodium chloride and dried over anhydrous magnesium sulfate, and then the solvent was distilled away under reduced pressure. The resulting residue was purified through silica gel column chromatography (hexane:ethyl acetate = 1:3) to afford methyl 3-(N,N-dimethylcarbamoyl)benzoate (2.30 g, 100 %).
References:
EP1700856,2006,A1 Location in patent:Page/Page column 135
1877-71-0
186 suppliers
$9.00/1g
506-59-2
570 suppliers
$5.00/5G
69383-71-7
15 suppliers
$45.00/100mg
1877-71-0
186 suppliers
$9.00/1g
124-40-3
547 suppliers
$18.00/100ml
69383-71-7
15 suppliers
$45.00/100mg
3441-03-0
45 suppliers
$137.84/1gm:
124-40-3
547 suppliers
$18.00/100ml
69383-71-7
15 suppliers
$45.00/100mg