METHYL 3-FLUORO-4-NITROBENZENECARBOXYLATE synthesis
- Product Name:METHYL 3-FLUORO-4-NITROBENZENECARBOXYLATE
- CAS Number:185629-31-6
- Molecular formula:C8H6FNO4
- Molecular Weight:199.14
in methanol;hexane;dichloromethane at 20; for 0.666667 h;Product distribution / selectivity;
Compound 236a: 3-Fluoro-4-nitro-benzoic acid methyl ester: A solution of 3-fluoro-4-nitro-benzoic acid (3.0 g, 16.12 mmol, 1.0 eq) in 4:1 DCM/MeOH (50 ml) was stirred at room temperature for 5 minutes and a 2.0M solution of TMS-diazomethane in hexanes (8.1 ml, 16.12 mmol, 1.0 eq) was added drop-wise over 10 minutes, the reaction then stirred at room temperature for 30 minutes. The reaction was quenched with a few drops of acetic acid and the solvent removed in vacuo to give the title compound (3.4 g, 17.09 mmol, 100% corrected). 1H NMR shows the desired product in ca. 90% purity.
DEVELOGEN AKTIENGESELLSCHAFT WO2006/136402, 2006, A1 Location in patent:Page/Page column 119