ChemicalBook CAS DataBase List METHYL 4'-BROMO[1,1'-BIPHENYL]-4-CARBOXYLATE

METHYL 4'-BROMO[1,1'-BIPHENYL]-4-CARBOXYLATE synthesis

11synthesis methods

Product Name:METHYL 4'-BROMO[1,1'-BIPHENYL]-4-CARBOXYLATE
CAS Number:89901-03-1
Molecular formula:C14H11BrO2
Molecular Weight:291.14

619-44-3
305 suppliers
$6.00/10g

5467-74-3
450 suppliers
$8.00/1g

METHYL 4'-BROMO[1,1'-BIPHENYL]-4-CARBOXYLATE

89901-03-1
70 suppliers
$53.00/1g

Yield: 93.62%

Reaction Conditions:

with (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;potassium carbonate in toluene at 90; for 12 h;Inert atmosphere;

Steps:

12.1 Step 1: 4'-Bromo-[1,1'-biphenyl]-4-carboxylic acid methyl ester
4-bromobenzeneboronic acid (460 mg, 2.3 mmol) was sequentially added to the drying reaction.Methyl 4-iodobenzoate (500 mg, 1.91 mmol),Potassium carbonate (528 mg, 3.82 mmol), (dppf) PdCl2 (140 mg, 0.19 mmol) and toluene (10 mL) were reacted at 90 ° C for 12 h under nitrogen. After the reaction,The reaction solution was filtered, and the filtrate was concentrated under reduced pressure.The residue obtained was subjected to silica gel column chromatography(PE/EtOAc(V/V)=50/1)purification,The title compound is a white solid(520 mg, 93.62%).

References:

Guangdong Dongyangguang Pharmaceutical Co., Ltd.;Ren Qingyun;Liu Xinchang;Huang Jianzhou;Zhang Yingjun;S ·geerdeman CN109111451, 2019, A Location in patent:Paragraph 0556; 0557; 0558; 0559