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1179999-39-3

methyl 4-hydroxy-5-nitropentanoate synthesis

2synthesis methods
-

Yield:1179999-39-3 71%

Reaction Conditions:

with potassium tert-butylate in tetrahydrofuran;tert-butyl alcohol at 0 - 20; for 24 h;Henry reaction;

References:

Gorczynski, Michael J.;Smitherman, Pamela K.;Akiyama, Taro E.;Wood, Harold B.;Berger, Joel P.;King, S. Bruce;Morrow, Charles S. [Journal of Medicinal Chemistry,2009,vol. 52,# 15,p. 4631 - 4639] Location in patent:experimental part