ChemicalBook CAS DataBase List Methyl 5-chloro-4-fluoro-1H-indole-2-carboxylate

Methyl 5-chloro-4-fluoro-1H-indole-2-carboxylate synthesis

8synthesis methods

Product Name:Methyl 5-chloro-4-fluoro-1H-indole-2-carboxylate
CAS Number:480450-89-3
Molecular formula:C10H7ClFNO2
Molecular Weight:227.62

2-Propenoic acid, 2-azido-3-(3-chloro-2-fluorophenyl)-, methyl ester

480450-90-6
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Methyl 5-chloro-4-fluoro-1H-indole-2-carboxylate

480450-89-3
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Yield:480450-89-3 440 mg

Reaction Conditions:

in 5,5-dimethyl-1,3-cyclohexadiene at 130 - 140; for 3 h;

References:

Yoshikawa, Kenji;Yokomizo, Aki;Naito, Hiroyuki;Haginoya, Noriyasu;Kobayashi, Shozo;Yoshino, Toshiharu;Nagata, Tsutomu;Mochizuki, Akiyoshi;Osanai, Ken;Watanabe, Kengo;Kanno, Hideyuki;Ohta, Toshiharu [Bioorganic and Medicinal Chemistry,2009,vol. 17,# 24,p. 8206 - 8220] Location in patent:experimental part

67-56-1 Synthesis