Methyl benzilate synthesis
- Product Name:Methyl benzilate
- CAS Number:76-89-1
- Molecular formula:C15H14O3
- Molecular Weight:242.27
Yield: 99%
Reaction Conditions:
with sulfuric acid;acetonitrile at 80 - 85; for 16 - 18 h;
Steps:
Procedure for ester (Table 2, entry 1-12 ):
General procedure: To a well-stirred mixture of acid (80 mmol), alcohol (90 mmol), acetonitrile (162 mmol) and sulfuric acid (98%, 94 mmol, 5 mL) was added at room temperature. Slowly heated to 80-85 °C and maintained between 80-85°C for16-18 h. The reaction mixture was cooled and added to 20% sodium carbonate solution (100mL). The reaction mass was extracted in CH2Cl2 (50 mL × 2). The combined organic layer was washed with water (100 mL), dried over sodium sufate, and concentrated under reduced pressure to obtain corresponding ester (97-99%) as the only product. Most example gave NMR pure product. Where minor impurities are formed, the product was purified over silica gel using ethyl acetate: petroleum ether (1:9).
References:
Dawar, Pankaj;Raju, M. Bagavan;Ramakrishna, Ramesha Andagar [Synthetic Communications,2014,vol. 44,# 6,p. 836 - 846] Location in patent:supporting information
3469-00-9
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76-89-1
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$23.60/50g
