Methyl thieno[2,3-b]pyridine-2-carboxylate synthesis
- Product Name:Methyl thieno[2,3-b]pyridine-2-carboxylate
- CAS Number:154650-88-1
- Molecular formula:C9H7NO2S
- Molecular Weight:193.22
36404-88-3
307 suppliers
$5.00/1g
2365-48-2
334 suppliers
$19.00/25g
154650-88-1
32 suppliers
$120.18/1gm:
Yield:154650-88-1 72%
Reaction Conditions:
with triethylamine in N,N-dimethyl-formamide at 100; for 3 h;
Steps:
30B Exam le 30B - methyl thienor2,3-blpyridine-2-carboxylate (B-130)
To a mixture of 2-chloronicotinaldehyde (10 g, 71 mmol) and methyl 2- mercaptoacetate (7.6 g, 71 mmol) in anhydrous N, N-dimethylformamide (100 mL) was added anhydrous triethylamine (14 g, 0.14 mol). The mixture was stirred at 100 °C for 3 hours. On completion, the solution was concentrated in vacuo and purified by silica gel column chromatography [petroleum ether : ethyl acetate = 10: 1 ] to give B-130 (10 g, 72% yield) as a white solid. LCMS: (ES+) m/z (M+H)+ = 194.1 , tR=0.671.
References:
WO2015/66371,2015,A1 Location in patent:Paragraph 00260-00261
60032-57-7
112 suppliers
$21.00/100mg
2365-48-2
334 suppliers
$19.00/25g
154650-88-1
32 suppliers
$120.18/1gm: