Methyl2-bromo-4-hydroxybenzoate synthesis
- Product Name:Methyl2-bromo-4-hydroxybenzoate
- CAS Number:101085-03-4
- Molecular formula:C8H7BrO3
- Molecular Weight:231.04
Yield: 100%
Reaction Conditions:
with thionyl chloride at 55;Cooling with ice;Inert atmosphere;
Steps:
56.56b Step 56b: Preparation of 2-bromo-4-hydroxybenzoic acid methyl 2-bromo-4-hydroxybenzoate (compound 0202-156):
Under nitrogen protection conditions,Combine 2-bromo-4-hydroxybenzoic acid (0201-156) (1.6 g, 7.4 mmol, 1 eq.)Dissolved in 30 ml of methanol,Thionyl chloride (4 ml) was slowly added dropwise in an ice bath.Warm up to 55°C to react overnight,After the reaction is complete, concentrate under reduced pressure, add water, extract with ethyl acetate, dry, spin dry,The product was obtained as a pale yellow solid, methyl 2-bromo-4-hydroxybenzoate (1.7 g, yield: 100%).
References:
Guangzhou Bi Beite Pharmaceutical Co., Ltd.;Cai Xiong;Qian Changgeng;Weng Yunwo;Qing Yuanhui;Liu Bin;Lin Mingsheng;Wang Yanyan CN107383024, 2017, A Location in patent:Paragraph 0482
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