MethylaMido Cyclopropanoate synthesis
- Product Name:MethylaMido Cyclopropanoate
- CAS Number:7108-40-9
- Molecular formula:C5H9NO
- Molecular Weight:99.13
Yield:7108-40-9 68%
Reaction Conditions:
in tetrahydrofuran at 20; for 12 h;
Steps:
132.A STEP A. Intermediate 132A. Preparation of N-methylcyclopropanecarboxamide
To a stirred solution of cyclopropanecarbonyl chloride (2.174 mL, 23.92 mmol) in THF (20 mL) at room temperature was added methanamine (33.5 mL, 67.0 mmol) and the reaction mixture was stirred for 12 h at room temperature. The reaction mixture was poured into saturated aqueous sodium bicarbonate solution (30 mL) and the aqueous layer was extracted with EtOAc (2x50 mL). The combined organic layers were dried over MgSCL, filtered and concentrated under reduced pressure to afford the title compound (1.6 g, 16.14 mmol, 68 % yield). NMR (400 MHz, DMSO-de) d 7.96 (br. s., 1H), 2.58 (d, J = 4.6 Hz, 3H), 1.57-1.43 (m, 1H), 0.70-0.54 (m, 4H).
References:
WO2020/168143,2020,A1 Location in patent:Page/Page column 299; 300
1759-53-1
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