N-(2-Chlorophenyl)-p-toluenesulfonamide synthesis
- Product Name:N-(2-Chlorophenyl)-p-toluenesulfonamide
- CAS Number:6380-05-8
- Molecular formula:C13H12ClNO2S
- Molecular Weight:281.76
Yield:6380-05-8 94%
Reaction Conditions:
with (Na1752K0.144Ca0365Mg0.065)(Al2044Si2774O96)*19.16H2O in ethanol at 25 - 30; for 0.333333 h;Sonication;Green chemistry;
Steps:
3.3 General procedure for the N-sulfonylation of amines by Natrolite nanozeolite under ultrasound irradiation
General procedure: The reactions were carried out in a round-bottomed flask of 25mL capacity suspended at the center of the cleaning bath, 5cm below the surface of the liquid. To the mixture of amine (1.0mmol) and tosyl chloride (1.0mmol) in 4mL of ethanol, Natrolite nanozeolite (0.08g) was added. The mixture was sonicated at 25-30°C (bath temperature, the temperature inside the reactor was also 25-30°C) for the appropriate time (Table 5) in an US bath having a frequency of 40kHz and an input power of 250W. The addition or removal of water controlled the temperature of the water bath. The water bath was controlled at 25-30°C. The progress of the reaction was monitored by TLC. After completion of the reaction, catalyst was filtrated. The filtrated catalyst, which was washed with ethyl acetate and activated at 100°C for 2h, could be reused in next cycle without considerable activity loss at least five successive runs for the same reaction. The solvent was concentrated under reduced pressure to afford the pure product as solid in good to excellent yields. All compounds were compared with the corresponding compounds prepared by the reported procedure [7,24-28]. All compounds were known and were characterized by spectral analysis.
References:
Nasrollahzadeh, Mahmoud;Ehsani, Ali;Rostami-Vartouni, Akbar [Ultrasonics Sonochemistry,2014,vol. 21,# 1,p. 275 - 282]
68-34-8
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