N-(3-INDOLYLMETHYLENE)-ISONICOTINIC HYDRAZONE synthesis
- Product Name:N-(3-INDOLYLMETHYLENE)-ISONICOTINIC HYDRAZONE
- CAS Number:10245-44-0
- Molecular formula:C15H12N4O
- Molecular Weight:264.28
Yield:10245-44-0 95%
Reaction Conditions:
with acetic acid in ethanol at 140; for 0.75 h;Microwave irradiation;
Steps:
4.2 General procedure for the synthesis of compounds 1a-o
General procedure: A mixture of isoniazid (1.0mmol), the respective aldehyde (1.0mmol) and one drop of glacial acetic acid in ethanol (6mL) was magnetic stirred under microwave irradiation for 45min (140°C, 1000rpm). The reaction mixture was filtered off and the solid was recrystallized with ethanol. The synthesis pathway is shown on scheme 1.
References:
Henriques, Ruan Roberto;Junior, Marcos Antonio de Abreu Lopes;Nogueira, Thayssa Lisboa do Couto;Romeiro, Nelilma Correia;Silva, Leandro Louback da;Farias, André Borges;Quimas, Jo?o Victor Fernandes;Santos, Daniela Corrêa;Souza, Andréa Luzia Ferreira de [Bioorganic and medicinal chemistry,2020]
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