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Isoniazid

Isoniazid
Isoniazid
CAS No.
54-85-3
Chemical Name:
Isoniazid
Synonyms
HIA;INH;INAH;fsr3;GINK;Cedin;FSR 3;fsr-3;Hyzyd;In-73
CBNumber:
CB5102053
Molecular Formula:
C6H7N3O
Formula Weight:
137.14
MOL File:
54-85-3.mol

Isoniazid Properties

Melting point:
171-173 °C(lit.)
Boiling point:
251.97°C (rough estimate)
Density 
1.2620 (rough estimate)
refractive index 
1.6910 (estimate)
Flash point:
>250°C
storage temp. 
Refrigerator
solubility 
125g/l
form 
Crystals or Crystalline Powder
color 
White or colorless
PH
6-8 (50g/l, H2O, 20℃)
Water Solubility 
14 g/100 mL (25 ºC)
Sensitive 
Air Sensitive
Merck 
14,5186
BRN 
119374
Stability:
Stability Stable, but may be air or light sensitive. Combustible. Incompatible with strong oxidizing agents, chloral, aldehydes, iodine, ferric salts, hypochlorites.
CAS DataBase Reference
54-85-3(CAS DataBase Reference)
NIST Chemistry Reference
Isoniazid(54-85-3)
EPA Substance Registry System
4-Pyridinecarboxylic acid, hydrazide(54-85-3)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn
Risk Statements  22-38-40-36/37/38
Safety Statements  37-36/37/39-26
RIDADR  2811
WGK Germany  3
RTECS  NS1751850
TSCA  Yes
PackingGroup  III
HS Code  29333999
Hazardous Substances Data 54-85-3(Hazardous Substances Data)
Toxicity LD50 in mice (mg/kg): 151 i.p., 149 i.v. (Jenney, Pfeiffer)
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
H371 May cause damage to organs Specific target organ toxicity, single exposure Category 2 Warning P260, P264, P270, P309+P311, P405,P501
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.
P501 Dispose of contents/container to..…

Isoniazid price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 75182 Isoniazid certified reference material, TraceCERT 54-85-3 50mg $132.5 2017-11-08 Buy
Sigma-Aldrich 1349706 Isoniazid United States Pharmacopeia (USP) Reference Standard 54-85-3 200mg $348.4 2017-11-08 Buy
TCI Chemical I0138 Isonicotinic Acid Hydrazide >98.0%(HPLC)(T) 54-85-3 25g $15 2017-11-08 Buy
TCI Chemical I0138 Isonicotinic Acid Hydrazide >98.0%(HPLC)(T) 54-85-3 100g $39 2017-11-08 Buy
Alfa Aesar A10583 Isonicotinic acid hydrazide, 98+% 54-85-3 50g $15.7 2017-11-08 Buy

Isoniazid Chemical Properties,Uses,Production

Chemical Properties

white crystalline powder

Uses

antibacterial, tuberculostatic

Uses

Antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Sele ctively induces expression of CYP2E1. Reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 at clinically relevant concentrations. Antib acterial (tuberculostatic).

Uses

For the treatment of all forms of tuberculosis in which organisms are susceptible.

Definition

ChEBI: A carbohydrazide obtained by formal condensation between pyridine-4-carboxylic acid and hydrazine.

General Description

Odorless colorless or white crystals or white crystalline powder. Taste is slightly sweet at first and then bitter. pH (1% aqueous solution) 5.5-6.5. pH (5% aqueous solution) 6-8.

Air & Water Reactions

Sensitive to air and light. Absorbs insignificant amounts of moisture at 77°F at relative humidities up to approximately 90%. Water soluble. Dust can be explosive when suspended in air at specific concentrations.

Reactivity Profile

Isoniazid is incompatible with chloral, aldehydes, iodine, hypochlorites and ferric salts. Isoniazid is also incompatible with oxidizers. Isoniazid may react with sugars and ketones. Isoniazid can react as a weak acid or a weak base. Isoniazid can be decomposed by oxidative and reductive reactions.

Fire Hazard

Isoniazid is combustible.

Purification Methods

Crystallise isoniazide from 95% EtOH and dry it in a vacuum. [Beilstein 22 III/IV 545, 22/2 V 219.]

Isoniazid Preparation Products And Raw materials

Raw materials

Preparation Products


Isoniazid Suppliers

Global( 329)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3218 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
inquiry@dakenchem.com CHINA 22144 58
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
+86-21-37127788 Candy@bj-chem.com CHINA 500 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20803 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32765 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
bruce@xrdchem.cn CHINA 511 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 10013 58
Wuhan Dahua Pharmaceutical Co., Ltd. 027-59262863 13277907145 QQ:3091977954
027-59420980 dh.luna@whdhwy.com China 4981 58
Wuhan Dahua Weiye Pharmaceutical Chemical Co., Ltd. 027-59262863 13277907145 QQ 3091977954
027-83322098 dh.luna@whdhwy.com China 2000 50
Wuhan DKY Technology Co.,Ltd. 027-81302488 18007166089
027-81302088 info@dkybpc.com;2851686510@qq.com China 1858 58

View Lastest Price from Isoniazid manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-20 Isoniazid
54-85-3
US $1.00 / KG 1KG 98% 100KG

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