N-(4-biphenyl)-(9,9-dimethylfluoren-2--yl)Amine synthesis
- Product Name:N-(4-biphenyl)-(9,9-dimethylfluoren-2--yl)Amine
- CAS Number:897671-69-1
- Molecular formula:C27H23N
- Molecular Weight:361.48
108714-73-4
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92-66-0
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897671-69-1
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Yield:897671-69-1 92%
Reaction Conditions:
with [Pd(N,N'-bis(2,6-bis(di-p-tolylmethyl)-4-methylphenyl)-imidazol-2-ylidene)(acetylacetonate)Cl];lithium hexamethyldisilazane in 1,4-dioxane at 110; for 3 h;Inert atmosphere;Sealed tube;Buchwald-Hartwig Coupling;
Steps:
2.3. Buchwald-Hartwig Cross-Coupling of Aryl Halides with Primaryor Secondary Amines: General Procedure
General procedure: A glassvial was charged with [Pd(IPr*me)(acac)Cl],neat amine (1.1 mmol), and the arylhalide (1 mmol) in dry 1,4-dioxane (1 mL) under an atmosphere of argonand sealed with a screw cap fitted with aseptum. LiHMDS (1.1 mmol) was subsequently injected at roomtemperature under argon, the reaction mixture was then refluxed at 110 for 3 h, After this time, dioxane was evaporated, the crude product wasdissolved in CH2Cl2. The solution was filtered on a padof silica covered with Celite, and thepad was eluted with CH2Cl2. After chromatography onsilica gel, the pure complex was obtained.
References:
Tian, Xiabing;Lin, Jing;Zou, Sheng;Lv, Junwei;Huang, Qingfei;Zhu, Jin;Huang, Shuping;Wang, Qiwei [Journal of Organometallic Chemistry,2018,vol. 861,p. 125 - 130] Location in patent:supporting information
28320-31-2
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92-67-1
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$15.90/1g
897671-69-1
251 suppliers
$6.00/250mg
92-66-0
581 suppliers
$10.00/1g
897671-69-1
251 suppliers
$6.00/250mg
98-80-6
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897671-69-1
251 suppliers
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106-40-1
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897671-69-1
251 suppliers
$6.00/250mg