N-METHOXY-N-METHYLTRIFLUOROACETAMIDE synthesis
- Product Name:N-METHOXY-N-METHYLTRIFLUOROACETAMIDE
- CAS Number:104863-67-4
- Molecular formula:C4H6F3NO2
- Molecular Weight:157.09
6638-79-5
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407-25-0
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104863-67-4
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Yield:104863-67-4 95%
Reaction Conditions:
with pyridine in dichloromethane at 0; for 1 h;Large scale;
Steps:
General procedure
To a suspension of N,O-dimethyl-hydroxylamine hydrochloride (107.2 Kg, 1.1 kmol) in dichloromethane (400 L) were added trifluoroacetic anhydride (210 Kg, 1 kmol) and pyridine (174 Kg, 2.2 kmol) sequentially at0 °C. The mixture was stirred at 0°C for 1 h and then diluted with ice water (300 L) and washed with 2 M HCl (300 L). The aqueous solution was extracted twice with dichloromethane and dried under MgSO4. The crude Weinreb amide was obtained after concentration without further purification (90 %purity, 95 % yield).
References:
Jiang;Cheng;Yuan [Asian Journal of Chemistry,2015,vol. 27,# 7,p. 2406 - 2408]
6638-79-5
587 suppliers
$6.00/25g
104863-67-4
149 suppliers
$5.00/250mg
6638-79-5
587 suppliers
$6.00/25g
76-05-1
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$9.00/1g
104863-67-4
149 suppliers
$5.00/250mg
354-32-5
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$55.00/10g
6638-79-5
587 suppliers
$6.00/25g
104863-67-4
149 suppliers
$5.00/250mg
407-25-0
468 suppliers
$9.00/1g
1117-97-1
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104863-67-4
149 suppliers
$5.00/250mg