N-Methyl-o-toluenesulfonamide synthesis
- Product Name:N-Methyl-o-toluenesulfonamide
- CAS Number:13440-22-7
- Molecular formula:C8H11NO2S
- Molecular Weight:185.2434
Yield:13440-22-7 96%
Reaction Conditions:
with [(Cp*IrCl)2(4,4′,6,6′-tetrahydroxy-2,2′-bipyrimidine)][Cl]2;potassium hydroxide in water at 130; for 12 h;
Steps:
4 N,2-dimethylbenzenesulfonamide
Combine o-methylbenzenesulfonamide (85.6 mg, 0.5 mmol), iridium catalyst (5.1 mg, 0.005 mmol, 1 mol%), potassium hydroxide (28 mg, 0.5 mmol, 1 equiv), then methanol (0.3 mL) and water (0.9 mL) were added to the reaction vessel in sequence. After the reaction mixture was reacted at 130 ° C for 12 hours in a reaction vessel, it was cooled to room temperature. The solvent was removed by rotary evaporation, and then the purified target compound was obtained by column chromatography (developing solvent: petroleum ether / ethyl acetate), yield: 96%.
References:
CN110857278,2020,A Location in patent:Paragraph 0040-0044
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