ChemicalBook CAS DataBase List N,N'-Diisopropylcarbodiimide

N,N'-Diisopropylcarbodiimide synthesis

7synthesis methods

Product Name:N,N'-Diisopropylcarbodiimide
CAS Number:693-13-0
Molecular formula:C7H14N2
Molecular Weight:126.2

Add N, N'diisopropylthiourea to the autoclave and use xylene as the solvent. The mass ratio of N, N'diisopropylthiourea to xylene solvent is 2:1. Add Sb2O4 catalyst (the amount of the catalyst is 1% of the total material), and oxygen is introduced. The temperature is increased to 115°C under a pressure of 8MPa for 4h, then lowered. Suction filtration at 15°C, decolorization, and vacuum distillation were used to obtain N, N'-Diisopropylcarbodiimide. The yield is 94.55%, and the purity is 99.55%.
N,N'-Diisopropylcarbodiimide

2986-17-6 Synthesis

2986-17-6
206 suppliers
$7.00/25g

693-13-0
515 suppliers
$13.00/1ml

Yield:693-13-0 99%

Reaction Conditions:

with cyclopentadienyl iron(II) dicarbonyl dimer in tetrahydrofuran at 60; for 24 h;Inert atmosphere;Reagent/catalyst;

Steps:

3-3 Examples 3-1 to 3-9 (Synthesis of various carbodiimide compounds)

To the reaction vessel, 0.3 mmol of the thiourea compound shown in Table 3, 0.9 mmol of [CpFe (CO) 2] 2 as in Example 1-2 as an iron compound and 9 mL of tetrahydrofuran were added and the mixture was stirred at 60 ° C. under a nitrogen atmosphere And allowed to react for 24 hours. However, only in Example 3-9, each charged amount was multiplied by 100/3 and carried out.After completion of the reaction, the resulting reaction solution was analyzed with a gas chromatograph mass spectrometer (GC-MS), and it was found that the product shown in Table 3 was produced at the yield shown in Table 3.The reaction solutions obtained in Examples 3-1 to 3-9 were cooled to room temperature, water was added, and the product was extracted with ethyl acetate. Subsequently, the organic layer was washed successively with water and saturated brine, dried over anhydrous magnesium sulfate, then filtered and concentrated to obtain a crude product, and the crude product was used in Examples 3-1 to 3-8, silica gel (Developing solvent: ethyl acetate / hexane (mixing ratio was appropriately adjusted)), and purified by distillation in Example 3-9 to obtain the respective products

References:

JP5999596,2016,B2 Location in patent:Paragraph 0054-0059; 0062; 0063; 0064

4128-37-4 Synthesis