N,N-DIMETHYL-3-NITROPYRIDIN-2-AMINE synthesis
- Product Name:N,N-DIMETHYL-3-NITROPYRIDIN-2-AMINE
- CAS Number:5028-23-9
- Molecular formula:C7H9N3O2
- Molecular Weight:167.17
1480-87-1
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5028-23-9
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Yield: 90%
Reaction Conditions:
with potassium carbonate in tetrahydrofuran;N,N-dimethyl-formamide for 16 h;
Steps:
1 Step 1: Synthesis of N,N-dimethyl-3-nitropyridin-2-amine (10-3) :
A DMF solution (1.0 ml/mmol) of 2-fluoro-3-nitro pyridine (1.0g, 7.0 mmol), dimethylamine in THF (2.0 M solution, 4.2 ml, 8.4 mmol) and K2CO3 (1.4g, 10.5 mmol) were heated to 100 °C in a sealed tube for 16 hours. TLC and LCMS of the reaction indicated complete consumption of starting material. The reaction mixture was quenched with water, extracted with ethyl acetate, and the organic layer was dried over Na2SO4 and evaporated to get crude material, which was purified using isolera column chromatography to afford N,N-dimethyl-3-nitropyridin-2-amine (1.05g, 6.3 mmol, 90.0% yield) as a yellow- colored solid, LCMS (ES+, m/z): 168.2 (M+1).
References:
SUMITOMO DAINIPPON PHARMA ONCOLOGY, INC.;SIDDIQUI-JAIN, Adam;SEENISAMY, Jeyaprakashnarayanan;WARNER, Steven, L.;WHATCOTT, Clifford, J.;BEARSS, David, J. WO2021/3417, 2021, A1 Location in patent:Paragraph 00296; 00303; 00310; 00314; 00320; 00340; 00346
5470-18-8
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821-09-0
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5028-23-9
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$58.00/100 mg
5470-18-8
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124-40-3
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$18.00/100ml
5028-23-9
39 suppliers
$58.00/100 mg
5470-18-8
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127-19-5
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5028-23-9
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$58.00/100 mg
5683-33-0
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2554-75-8
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5028-23-9
39 suppliers
$58.00/100 mg