N-phenyl-N-[4-(trifluoromethyl)phenyl]-Urea synthesis
- Product Name:N-phenyl-N-[4-(trifluoromethyl)phenyl]-Urea
- CAS Number:23750-69-8
- Molecular formula:C14H11F3N2O
- Molecular Weight:280.2451
Yield: 61%
Reaction Conditions:
with sodium acetate in methanol at 60; for 2 h;
Steps:
22 Embodiment 22 A method for producing a urea compound, which comprises preparing a compound represented by Formula I-v
The preparation steps were as follows: a magnetic, 3-phenyl-1,4,2-dioxazol-5-one (0.3 mmol) was added to a 10 mL round bottom flask in air. Sodium acetate (0.3 mmol) and methanol (1 mL), A further substituted amine (0.3 mmol) was added under stirring. Then, the rubber stopper was stoppered and heated and stirred in an oil bath at 60 ° C for 2 hours. After completion of the reaction, petroleum ether/ethyl acetate was used as a mobile phase, and the product was purified by flash silica gel column chromatography.
References:
Zhejiang University;Zou Hongbin;Su Pakaqingmai;Zhang Jinquan CN109776244, 2019, A Location in patent:Paragraph 0114-0117
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