N1,N3-BIS(3-METHYLPHENYL)MALONAMIDE synthesis
- Product Name:N1,N3-BIS(3-METHYLPHENYL)MALONAMIDE
- CAS Number:116476-70-1
- Molecular formula:C17H18N2O2
- Molecular Weight:282.34
Yield: 56%
Reaction Conditions:
with triethylamine in 1,4-dioxane at 0; for 1 h;
Steps:
4.2.1. Preparation of malonyl diamide derivatives (100-111)
General procedure: Malonyl diamide derivatives were prepared as described earlier.49 Briefly: To a magnetically stirred ice bath-cooled solution of the selected amine (14 mmol), and triethylamine (14 mmol, 1.4 g) in dioxane (20 ml), malonyl dichloride (1.0 g, 7.0 mmol) solution in dioxane (20 ml) was added dropwise over 15 min. The reaction mixture was stirred at 0 °C for one hour. Subsequently, HCl (2 N, 50 ml) was added to the reaction suspension and stirred for 30 minutes. Finally, the mixture was filtered to afford the products as whitish to gray solids that were further washed by stirring in water (50 mL) for 30 min (Scheme 1).
References:
Habash, Maha;Taha, Mutasem O. [Bioorganic and Medicinal Chemistry,2011,vol. 19,# 16,p. 4746 - 4771] Location in patent:experimental part
