ChemicalBook CAS DataBase List NALBUPHINE

NALBUPHINE synthesis

3synthesis methods

Product Name:NALBUPHINE
CAS Number:85284-04-4
Molecular formula:C21H27NO4
Molecular Weight:357.44

(5alpha)-4,5-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride

52446-24-9
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85284-04-4
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20594-83-6 Synthesis

20594-83-6
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Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: acetic acid; tetramethylammonium triacetoxyborohydride / N,N-dimethyl-formamide / 20 °C
1.2: 60 °C
2.1: sodium tetrahydroborate / dimethyl sulfoxide / 60 °C

References:

Chen, Yibo;Wu, Zenong;Yang, Zhezhou;Zhang, Fuli;Zhang, Tao;Zhao, Weili [Organic Process Research and Development,2020,vol. 24,# 9,p. 1707 - 1717]

FullText

16676-33-8
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85284-04-4
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20594-83-6 Synthesis

20594-83-6
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References

33522-95-1 Synthesis

33522-95-1
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$60.60/013-1ml

85284-04-4
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20594-83-6 Synthesis

20594-83-6
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References

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