nalbuphine synthesis
- Product Name:nalbuphine
- CAS Number:20594-83-6
- Molecular formula:C21H27NO4
- Molecular Weight:357.45
23277-43-2
0 suppliers
$83.90/051-1ml
20594-83-6
0 suppliers
inquiry
Yield: 97%
Reaction Conditions:
with hydrogenchloride;potassium carbonate;sodium chloride in water; pH=9.3
Steps:
1
Nalbuphine hydrochloride dihydrate (600 mg, from Sigma) was dissolved in water (100 mL). Saturated aqueous K2CO3 was added and then adjusted the pH to 9.3 with 1 N HCl solution, saturated with sodium chloride. The solution was extracted with dichloromethane (5 x 25 mL). The combined organic solution was washed with brine (100 mL), dried over Na2SO4, concentrated to dryness and dried under high vacuum to yield nalbuphine (483.4 mg, 97% recovery). The product was confirmed by 1H-NMR in CDCl3.
References:
Location in patent:Page/Page column 42
16676-33-8
8 suppliers
inquiry
20594-83-6
0 suppliers
inquiry
2987-17-9
139 suppliers
$10.00/250mg
33522-95-1
93 suppliers
$60.60/013-1ml
20594-83-6
0 suppliers
inquiry
![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
0 suppliers
inquiry
20594-83-6
0 suppliers
inquiry
