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ChemicalBook CAS DataBase List Paroxetine Related Impurity 9

Paroxetine Related Impurity 9 synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 4 steps
1.1: sodium methylate
2.1: lithium aluminium tetrahydride / tetrahydrofuran
3.1: (2S,3S)-di-4-toluoyltartaric acid
4.1: toluene / 3.75 h / 100 - 105 °C / Large scale reaction
4.2: 1 h / 60 °C
4.3: 25 - 35 °C

References:

Gangula, Srinivas;Kolla, Naveen Kumar;Elati, Chandrasekar;Dongamanti, Ashok;Bandichhor, Rakeshwar [Synthetic Communications,2012,vol. 42,# 22,p. 3344 - 3360]

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