Piperidine, 4-(1H-pyrazol-1-yl)- (9CI) synthesis
- Product Name:Piperidine, 4-(1H-pyrazol-1-yl)- (9CI)
- CAS Number:762240-09-5
- Molecular formula:C8H13N3
- Molecular Weight:151.21
1269429-29-9
762240-09-5
Step C: Synthesis of 4-(1H-pyrazol-1-yl)piperidine (i-4) The tert-butyl 4-(1H-pyrazol-1-yl)piperidine-1-carboxylate (50 mg, 0.2 mmol) obtained from Step B was dissolved in a dioxane solution (2.0 mL) of 4M HCl. The reaction mixture was stirred at room temperature for 1 hour. Subsequently, the solvent was removed by concentration under reduced pressure and dried under high vacuum to afford the white solid product 4-(1H-pyrazol-1-yl)piperidine (i-17) (30 mg, 96% yield). The product was analyzed by ESI-MS and the calculated value (C8H13N3) was 151.11 and the measured value was 151.11 [M+H]+, found to be 152.10.
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Yield: 96%
Reaction Conditions:
with hydrogenchloride in 1,4-dioxane at 20; for 1 h;
Steps:
Step C: 4-(1H-pyrazol-1-yl)piperidine (i-4)
Step C: 4-(1H-pyrazol-1-yl)piperidine (i-4) (0094) The title compound from Step B above (50 mg, 0.2 mmol) was dissolved in 4 M HCl in dioxane (2.0 mL) and stirred at RT for 1 h. The product was concentrated under reduced pressure and dried under high vacuum to give the title compound (i-17) (30 mg, 96%). ESI-MS calculated for C8H13N3: Exact Mass: 151.11; Found 152.10.
References:
Merck Sharp & Dohme Corp.;MORRIELLO, Gregori, J.;CHANG, Lehua;EDMONDSON, Scott, D. EP2632457, 2017, B1 Location in patent:Paragraph 0088; 0094
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762240-09-5
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