ChemicalBook CAS DataBase List Prednisolone-21-acetate

Prednisolone-21-acetate synthesis

9synthesis methods

Product Name:Prednisolone-21-acetate
CAS Number:52-21-1
Molecular formula:C23H30O6
Molecular Weight:402.49

50-24-8 Synthesis

50-24-8
572 suppliers
$16.39/100mg

108-24-7
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$14.00/250ML

52-21-1
422 suppliers
$29.00/100mg

Yield:52-21-1 99.8%

Reaction Conditions:

with 4-dimethylaminopyridine in N,N-dimethyl-formamide at 40; for 0.5 h;Inert atmosphere;

Steps:

1-5 Example 4 Preparation of Compound 2

Under N2 protection, prednisolone 3 (20g, 55.49mmol),100ml of N, N-dimethylformamide (DMF) was added to the reaction flask,The solution was stirred at room temperature.4-dimethylaminopyridine (DMAP, 7.45 g, 60.98 mmol) was added in that order,Acetic anhydride (8.50 g, 83.25 mmol). The mixture was heated to 40 ° C and stirred for 30 minutes.Cool to room temperature, pour into 500ml ice water, and stir for 30min under ice bath conditions.Vacuum filtration, washing with water, and drying to obtain crude product 2 (22.29 g, 99.8%);

References:

CN110540569,2019,A Location in patent:Paragraph 0056-0065