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ChemicalBook CAS DataBase List PROPIOIN
4984-85-4

PROPIOIN synthesis

7synthesis methods
-

Yield:4984-85-4 86.47%

Reaction Conditions:

with 1-butyl-1H-1,3-benzodiazole hydrochloride at 100; under 4500.45 Torr; for 1.5 h;

Steps:

3.2 (2) c acyloin preparation
Under the condition of stirring, to the reaction kettle is added 500g of propionaldehyde and 3.5g of N - butyl and imidazole hydrochloride, propionaldehyde and 1 - is butyl and imidazole hydrochloride in the weight ratio of 143:1, the reaction temperature is controlled to 100 °C, reaction pressure 0.6 mpa, reaction time 1.5h, thereby obtaining a reaction fluid altogether 495g; the reaction liquid by distillation under reduced pressure, collecting distillate at a temperature of 100 - 140 °C and get between the third acyloin 436g. Gas chromatographic analysis, as shown in Figure 2 and table 2 shown, c acyloin content is 99.47%, c acyloin of yield is 86.47%.

References:

Puyang Tianyuan Biological Technology Co., Ltd.;Zheng Dagang;Li Pengyi;Yang Hefeng;Cai Cunxian;Wen Jiaogang;Lv Xiaoyong CN106397151, 2017, A Location in patent:Paragraph 0018; 0019; 0021; 0022

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