PYRIDINE-3,5-DICARBOXYLIC ACID MONOETHYL ESTER synthesis
- Product Name:PYRIDINE-3,5-DICARBOXYLIC ACID MONOETHYL ESTER
- CAS Number:84254-37-5
- Molecular formula:C9H9NO4
- Molecular Weight:195.17
4591-56-4
93 suppliers
$45.00/100mg
84254-37-5
24 suppliers
$155.00/100mg
Yield:84254-37-5 71%
Reaction Conditions:
with potassium hydroxide in ethanol at 20; for 2 h;
Steps:
The white solid (8 g, 0.035 mol) was slowly added to ethanol solution that containing potassium hydroxide (1 g, 0.018 mol). After stirring at room temperature for 2 hours, a large number of white solids were precipitated, which would be filtered out and then dissolved in distilled water. After filtering out insoluble substance, HCl solution was slowly dripped into the aqueous solution to adjust its pH value to 3. During the adjustment process, white solid would appear continuously. After filtering, pyridine 3,5-dicarboxylic acid with unilateral protection could be obtained in 71% yield.
References:
Zhang, Tong;Bai, Cui-Bing;Wu, Yue-Hua;Wang, Nai-Xing;Xu, Bao-Cai;Yan, Zhan;Xing, Yalan [Synthetic Communications,2019,vol. 49,# 3,p. 410 - 416] Location in patent:supporting information
499-81-0
302 suppliers
$7.00/5g
64-17-5
700 suppliers
$10.00/50g
84254-37-5
24 suppliers
$155.00/100mg
4591-56-4
93 suppliers
$45.00/100mg
499-81-0
302 suppliers
$7.00/5g
84254-37-5
24 suppliers
$155.00/100mg