ChemicalBook CAS DataBase List Pyridine hydrochloride

Pyridine hydrochloride synthesis

8synthesis methods

Product Name:Pyridine hydrochloride
CAS Number:628-13-7
Molecular formula:C5H5N.ClH
Molecular Weight:115.56

Pyridine hydrochloride could be synthesized through the liquid-liquid synthesis method (pyridine and hydrochloric acid) and the gas-liquid synthesis method (pyridine and hydrogen chloride gas) respectively. The yield of the liquid-liquid synthesis method was 85% and the gas-liquid synthesis method was 92%.

54562-14-0 Synthesis

54562-14-0
11 suppliers
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56-81-5 Synthesis

56-81-5
1611 suppliers
$5.00/25g

628-13-7
406 suppliers
$9.00/25g

14465-68-0 Synthesis

14465-68-0
47 suppliers
$28.00/10mg

Yield:14465-68-0 96.3%

Reaction Conditions:

with pyridine;dmap in dichloromethane at 20 - 35;

Steps:

1.1

Example 1: synthesis OF TRIGAMMALINOLENIN 1) Acid chloride method 2.0 g (7.2 mmol, 3.1 equiv) GLA95 (95% pure y-linolenic acid) was dissolved in 10 ml DCM. L. Olg (0.71 ml, 8.0 mmol, 3.4 equiv) oxalyl chloride in 5 ml DCM added dropwise over 2-3 min under nitrogen. Stirred at RT overnight. Reaction mixture concentrated in vacuo to remove DCM and excess oxalyl chloride. This acid chloride was then added dropwise over 2-3 min to a stirred mixture of 215 mg (2.3 mmol, 1 equiv) of glycerol, 0.58 ml (3.1 equiv) pyridine and 10 ml DCM under nitrogen. The mixture was stirred at RT overnight. The pyridine hydrochloride formed was then filtered off and washed with DCM. The solution was washed 1 x 4 ml water, 0. 1N HC1, 5% sodium bicarbonate and 5% NaCl. Dried over magnesium sulphate, filtered and concentrated in vacuo to a yellow oil. This oil was purified on a silica column using 10% ether in hexane as eluting solvent. A clear colourless oil was obtained, a sample of which was trans- esterified and subsequently analysed by GC. The product contained 96.3% GLA

References:

WO2005/18632,2005,A1 Location in patent:Page/Page column 22-23

62147-49-3 Synthesis