ChemicalBook CAS DataBase List Quinagolide

Quinagolide synthesis

10synthesis methods

Product Name:Quinagolide
CAS Number:87056-78-8
Molecular formula:C20H33N3O3S
Molecular Weight:395.56

(+/-)-(3α,4aα,10aβ)-1,2,3,4,4a,5,10,10a-octahydro-6-methoxy-3-(methoxycarbonyl)benzoquinoline

87056-65-3
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87056-78-8
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Yield:-

Steps:

Multi-step reaction with 6 steps
1: H₂ / 10percent Pd/C / propan-1-ol / Ambient temperature
2: 80 percent / H₂NNH₂*H₂O / methanol / 20 h / 50 °C
3: NOCl / tetrahydrofuran / 1 h / Heating
4: aq. HCl / tetrahydrofuran / 1 h / Heating; 1.) THF, reflux, 1 h, 2.) THF, reflux, 1 h
5: 87 percent / Et₃N / CHCl₃ / 50 °C
6: BBr₃ / CH₂Cl₂ / 4 h / -10 °C

References:

Nordmann;Petcher [Journal of Medicinal Chemistry,1985,vol. 28,# 3,p. 367 - 375]

Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

1000210-73-0
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87056-78-8
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References

1000210-73-0
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87056-78-8
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References

1000210-73-0
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87056-78-8
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References

1000210-73-0
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87056-78-8
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References

Quinagolide Related Search:

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