(R,R)-1,2-bis(methanesulfonyloxymethyl)cyclohexane synthesis
- Product Name:(R,R)-1,2-bis(methanesulfonyloxymethyl)cyclohexane
- CAS Number:186204-35-3
- Molecular formula:C10H20O6S2
- Molecular Weight:300.39
65376-05-8
345 suppliers
$5.00/1g
124-63-0
6 suppliers
$10.00/5g
186204-35-3
245 suppliers
$8.00/250mg
Yield:186204-35-3 92.6%
Reaction Conditions:
with triethylamine at 0 - 5;Industrial scale;
Steps:
7
Intermediate 1 (10.6 kg, 73.5 mol) is dissolved in a mixture of methylisobutyl ketone (315 1) and triethylamine (35 1). The solution is then cooled tobetween 0°C and 5°C, and mesyl chloride (11.7 1, 151 mol) is added in 60 minutes. After the addition, the mass is stirred until the reaction is complete, and water (315 1) is added. The two phases are then separated, and the organic phase is concentrated to obtain a solution containing 20.44 kg of 2, yield 92.6%.
References:
WO2015/56205,2015,A1 Location in patent:Page/Page column 14
65376-05-8
345 suppliers
$5.00/1g
124-63-0
6 suppliers
$10.00/5g
186204-35-3
245 suppliers
$8.00/250mg
46022-05-3
297 suppliers
$9.00/1g
186204-35-3
245 suppliers
$8.00/250mg
2305-32-0
259 suppliers
$10.00/5g
186204-35-3
245 suppliers
$8.00/250mg
140459-96-7
25 suppliers
$130.00/1g
186204-35-3
245 suppliers
$8.00/250mg