Raltitrexed synthesis
- Product Name:Raltitrexed
- CAS Number:112887-68-0
- Molecular formula:C21H22N4O6S
- Molecular Weight:458.49
![Diethyl N-[5-[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-methylamino]-2-thenoyl]-L-glutamate](/CAS/GIF/132463-02-6.gif)
132463-02-6
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112887-68-0
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Yield:112887-68-0 80%
Reaction Conditions:
with sodium hydroxide in water at 25;
Steps:
9 Preparation of Compound 1
To the reaction flask, 1.35 g of sodium hydroxide and 3.3 ml of water were added, and the mixture was cooled to 25 °C or lower, and 1.35 g of the starting material (Compound 2) was slowly added with stirring. The mixture was further stirred for 1.5 to 2 hours, and then the reaction solution (2 × 27ml), water phase filtration. The filtrate was stirred with 2M hydrochloric acid to adjust the pH to 3.0, and the mixture was stirred for 2 hours. The product was washed with distilled water and the solid was dried under vacuum at 80 °C for 10 hours to give 0.96 g of product, 80% yield and 99.5% HPLC purity.
References:
CN106957296,2017,A Location in patent:Paragraph 0064; 0065
![L-Glutamic acid, N-[(5-amino-2-thienyl)carbonyl]-, 1,5-diethyl ester](/CAS/20210305/GIF/106585-63-1.gif)
106585-63-1
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![Diethyl N-[5-methylamino-2-thenoyl]-L-glutamate](/CAS/GIF/112889-02-8.gif)
112889-02-8
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$23.00/250mg
112887-68-0
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![L-Glutamic acid, N-[(5-nitro-2-thienyl)carbonyl]-, 1,5-diethyl ester](/CAS/20210305/GIF/106585-64-2.gif)
106585-64-2
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112887-68-0
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112888-43-4
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$75.00/1g
112887-68-0
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$28.00/1unit