ChemicalBook CAS DataBase List Milrinone

Milrinone synthesis

9synthesis methods

Product Name:Milrinone
CAS Number:78415-72-2
Molecular formula:C12H9N3O
Molecular Weight:211.22

1692-15-5 Synthesis

1692-15-5
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5-Bromo-3-cyano-2-hydroxy-6-methylpyridine

84725-13-3
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78415-72-2
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$5.00/50mg

Yield:78415-72-2 72.5%

Reaction Conditions:

with tetrakis(triphenylphosphine) palladium⁽⁰⁾;sodium hydroxide in water;toluene for 18 h;Reflux;Inert atmosphere;Suzuki Coupling;

Steps:

3 Example 3
21.3 g of compound 3, 12.9 g of 4-pyridineboronic acid, 50 ml of toluene, 50 ml of a 2M aqueous solution of sodium hydroxide, 2.3 g of tetrakis(triphenylphosphine)palladium, were added in the reaction vessel, and refluxed under a nitrogen atmosphere for 18 hours, Cooled to room temperature, 10ml 50% aqueous sodium hydroxide was added, stirred for 15min, the aqueous layer was separated, the aqueous layer was adjusted with acetic acid ρΗ = about 6, solid precipitated, yield obtained 15.3g white solid milrinone (yield 72.5%).

References:

Hunan Sailong Pharmaceutical Co., Ltd.;Long Zhixiang;Li Jianfeng;Zhu Keming;Wu Biao;Zhou Wen;Xie Xuejuan CN105037261, 2017, B Location in patent:Paragraph 0054; 0055

6304-16-1 Synthesis