RARECHEM AL BI 0500 synthesis
1synthesis methods
- Product Name:RARECHEM AL BI 0500
- CAS Number:86239-00-1
- Molecular formula:C10H11FO2
- Molecular Weight:182.19
Yield:86239-00-1 96%
Reaction Conditions:
with thionyl chloride at 0 - 60;
Steps:
To a solution of 3-fluoro-4-methylbenzoic acid (13.23 g, 85.85 mmol) in EtOH (200 mL) at 0 °C was added SOCl2 (3 mL) dropwise. The reaction mixture was heated at 60 °C overnight, then cooled to room temperature, concentrated under reduced pressure and diluted with DCM. The organic layer was washed with IN NaOH (100 mL x 2), dried (MgS04) and concentrated to give ethyl 3-fluoro-4-methylbenzoate (15.02 g, 96 %).
References:
WO2011/71565,2011,A1 Location in patent:Page/Page column 163