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ChemicalBook CAS DataBase List Rosmarinic acid

Rosmarinic acid synthesis

14synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 6 steps
1: 100 percent / H2 / 5percent Pd/C / ethanol / 3750.3 Torr
2: 1.) K2CO3, EtOH, 2.) KOH / 1.) reflux, 5 h, 2.) 12 h
3: 96 percent / tetrahydrofuran / 48 h / 50 °C
5: 94 percent / DMAP, DCC / CH2Cl2 / 12 h / -20 - 20 °C
6: 92 percent / Pd(PPh3)4, morpholine / tetrahydrofuran / Ambient temperature

References:

Eicher, Theophil;Ott, Markus;Speicher, Andreas [Synthesis,1996,# 6,p. 755 - 762]

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