ChemicalBook CAS DataBase List (S)-4-PHENYL-1,3-OXAZOLIDINE-2-THIONE

(S)-4-PHENYL-1,3-OXAZOLIDINE-2-THIONE synthesis

7synthesis methods

Product Name:(S)-4-PHENYL-1,3-OXAZOLIDINE-2-THIONE
CAS Number:190970-57-1
Molecular formula:C9H9NOS
Molecular Weight:179.24

99395-88-7 Synthesis

99395-88-7
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190970-57-1
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$118.00/1g-f

Yield:190970-57-1 91.6%

Reaction Conditions:

with sulfur in water at 40 - 50; for 8 h;Inert atmosphere;Reagent/catalyst;

Steps:

4-5 Example 4
Under the protection of nitrogen, 25g (0.153mol) of (S)-4-phenyl-2-oxazolidinone and 5.2g (0.161mol) of high-purity sulfur In the adsorption reaction flask, drop 87.8g (0.161mol) of 30% ammonia polysulfide aqueous solution at room temperature. After the addition, heat to 40-50°C reaction for 8 hours, sampling of raw materials is less than 0.5%. The aqueous phase was extracted once more with MTBE, combined with MTBE, concentrated, and recrystallized by adding n-heptane/acetic acid (6/1) under heating.Filter and dry to obtain 25.2 g of (S)-4-phenyl-2-oxazolidinthione, HPLC: 99.2%, yield 91.6%.

References:

CN112500361, 2021, A Location in patent:Paragraph 0034-0039

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