STATIL synthesis
- Product Name:STATIL
- CAS Number:72702-95-5
- Molecular formula:C17H12BrFN2O3
- Molecular Weight:391.19
76283-09-5
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$9.00/1g
25947-13-1
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$33.39/250mg
72702-95-5
88 suppliers
$25.00/5mg
Yield: 54%
Reaction Conditions:
Stage #1:ethyl 1,2-dihydro-1-oxophthalazin-4-ylacetate with sodium hydroxide in tetrahydrofuran at 40 - 50; for 0.5 h;
Stage #2:4-bromo-2-fluorobenzyl bromide in tetrahydrofuran at 50 - 60; for 2 h;
Stage #3: with acetic acid in tetrahydrofuran;water; pH=2 - 3
References:
Sriram, Dharmarajan;Yogeeswari, Perumal;Senthilkumar, Palaniappan;Sangaraju, Dewakar;Nelli, Rohit;Banerjee, Debjani;Bhat, Pritesh;Manjashetty, Thimmappa H. [Chemical Biology and Drug Design,2010,vol. 75,# 4,p. 381 - 391] Location in patent:experimental part