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Sucralose

Sucralose
Sucralose structure
CAS No.
56038-13-2
Chemical Name:
Sucralose
Synonyms
TGS;E955;SUCRALOSE;SPLENDA [R];SUCRALOSE(P);Sucralose99%;ctopyranoside;Sucralose, NF;loro-4-deoxy-;Sucralose 0.1
CBNumber:
CB9363034
Molecular Formula:
C12H19Cl3O8
Formula Weight:
397.63
MOL File:
56038-13-2.mol

Sucralose Properties

Melting point:
115-1018°C
alpha 
D +68.2° (c = 1.1 in ethanol)
Boiling point:
104-107 C
Density 
1.375 g/cm
storage temp. 
Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility 
Do you have solubility information on this product that you would like to share
form 
Powder
pka
12.52±0.70(Predicted)
color 
White
PH
6-8 (100g/l, H2O, 20°C)
optical activity
[α]/D 86.0±2.0°, c = 1 in H2O
Water Solubility 
Soluble in Water.
Merck 
14,8880
BRN 
3654410
CAS DataBase Reference
56038-13-2(CAS DataBase Reference)
FDA 21 CFR
172.831; 101.80
Substances Added to Food (formerly EAFUS)
SUCRALOSE
EWG's Food Scores
1
FDA UNII
96K6UQ3ZD4
EPA Substance Registry System
.alpha.-D-Galactopyranoside, 1,6-dichloro-1,6-dideoxy-.beta.-D-fructofuranosyl 4-chloro-4-deoxy- (56038-13-2)
SAFETY
  • Risk and Safety Statements
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-37/39-24/25
WGK Germany  3
RTECS  LW5440140
HS Code  2932 14 00
Toxicity LD50 orally in Rabbit: > 10000 mg/kg

Sucralose price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 69293 Sucralose ≥98.0% (HPLC) 56038-13-2 100g $129 2020-08-18 Buy
Sigma-Aldrich 1623626 Sucralose United States Pharmacopeia (USP) Reference Standard 56038-13-2 400mg $414 2020-08-18 Buy
TCI Chemical S0839 Sucralose >98.0%(HPLC) 56038-13-2 5g $31 2020-06-24 Buy
TCI Chemical S0839 Sucralose >98.0%(HPLC) 56038-13-2 25g $86 2020-06-24 Buy
Alfa Aesar J66736 Sucralose 98% 56038-13-2 100g $93.8 2020-06-24 Buy

Sucralose Chemical Properties,Uses,Production

Chemical Properties

Off-White Amorphous Solid

Chemical Properties

Sucralose is a white to off-white colored, free-flowing, crystalline powder.

History

Sucralose, 1,6-dichloro-1,6-dideoxy-β-D-fructofuranosyl- 4-chloro-4-deoxy-α-D-galactopyranoside, is a trichloro-galactosucrose sweetener developed by the British sugar company Tate & Lyle during the 1970s (U.S. Pat. 4,343,934 (Aug. 10, 1982), M. R. Jenner and D. Waite (to Talres Development), (U.S. Pat. 4,362,869 (Dec. 7, 1982), M. R. Jenner and co-workers (to Talres Development), and (U.S. Pat. 4,435,440 (Mar. 6, 1984), L. Hough, S. P. Phadnis, and R. A. Khan (to Tate & Lyle). It was licensed to McNeil-PPC, Inc., a Johnson & Johnson subsidiary, in the United States until a new agreement took place in February, 2004. McNeil Nutritionals retained ownership of SPLENDA Brand and the right for its worldwide retail and food service business. Tate & Lyle became the sole manufacturer of SPLENDA Brand sucralose and owned the right for its worldwide ingredient sales.

Uses

High intensity sweetener manufactured by replacing three hydroxyl groups on the sucrose molecule with three chlorine atoms. The results are a sweetener of 0 cal that is not digested. It is 600 times as sweet as sugar with a similar flavor profile. It is heat stable, readily soluble, and maintains its stability at elevated temperatures. It has been approved for use in specific categories that include baked products, beverages, confectioneries, and certain desserts and toppings.

Uses

Sucralose (1,6-dichloro-1,6-dideoxy-p-fructofuranosyl-4-chloro-oc- D-galactopyra- noside) is a nonnutritive sweetener based on sucrose. It is selectively chlorinated and the glycoside link between the two rings is resistant to hydrolysis by acid or enzymes, so it is not metabolized. It has 400 to 800 times the sweetness of sucrose, is very soluble in water, and is stable in heat. It can be used in food products that are baked or fried.
Sucralose is produced by the selective chlorination of the sucrose molecule using a patented process by Tate and LyIe that replaces the three hydroxyl groups (OH) with three chlorine (Cl) atoms.
This modified sugar is minimally absorbed by the body and passes out unchanged. It was approved for use in foods and beverages in 1999 in the United States.

Uses

A low-calorie artificial sweetener

Uses

antiprotozoal

Definition

ChEBI: A disaccharide derivative consisting of 4-chloro-4-deoxy-alpha-D-galactopyranose and 1,6-dichloro-1,6-dideoxy-beta-D-fructofuranose units linked by a glycosidic bond.

Production Methods

Sucralose may be prepared by a variety of methods that involve the selective substitution of three sucrose hydroxyl groups by chlorine. Sucralose can also be synthesized by the reaction of sucrose (or an acetate) with thionyl chloride.

Pharmaceutical Applications

Sucralose is used as a sweetening agent in beverages, foods, and pharmaceutical applications. It has a sweetening power approximately 300–1000 times that of sucrose and has no aftertaste. It has no nutritional value, is noncariogenic, does not promote dental caries, and produces no glycemic response.

Safety

Sucralose is generally regarded as a nontoxic and nonirritant material and is approved, in a number of countries, for use in food products. Following oral consumption, sucralose is mainly unabsorbed and is excreted in the feces.
The WHO has set an acceptable daily intake for sucralose of up to 15 mg/kg body-weight.
LD50 (mouse, oral): > 16 g/kg
LD50 (rat, oral): > 10 g/kg

storage

Sucralose is a relatively stable material. In aqueous solution, at highly acidic conditions (pH < 3), and at high temperatures (≤35℃), it is hydrolyzed to a limited extent, producing 4-chloro-4- deoxygalactose and 1,6-dichloro-1,6-dideoxyfructose. In food products, sucralose remains stable throughout extended storage periods, even at low pH. However, it is most stable at pH 5–6.
Sucralose should be stored in a well-closed container in a cool, dry place, at a temperature not exceeding 21℃. Sucralose, when heated at elevated temperatures, may break down with the release of carbon dioxide, carbon monoxide, and minor amounts of hydrogen chloride.

Regulatory Status

The FDA, in April 1998, approved sucralose for use as a tabletop sweetener and as an additive in a variety of food products. In the UK, sucralose was fully authorized for use in food products in 2005. It is also accepted for use in many other countries worldwide. Included in the Canadian List of Acceptable Nonmedicinal Ingredients.

Sucralose Preparation Products And Raw materials

Raw materials

Preparation Products


Sucralose Suppliers

Global( 444)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Jiangxi alpha high tech Pharmaceutical Co., Ltd
86-51085010237
overseamarketing@alphahi-tech.com CHINA 41 58
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21841 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22624 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 2754 55
Hebei Chishuo Biotechnology Co., Ltd.
13292891350 +86 311 66567340
luna@speedgainpharma.com CHINA 1005 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30039 58
Shaanxi Yikanglong Biotechnology Co., Ltd.
17791478691
yklbiotech@163.com CHINA 297 58
Hebei Huanhao Biotechnology Co., Ltd.
+8618034552304
86-0311-83975816 cathylee@hbhuanhao.com CHINA 837 58

View Lastest Price from Sucralose manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-05-29 Sucralose
56038-13-2
US $25.00 / KG 1KG 98.0%~102.0% 200 Ton/Tons per Month Sucralose Henan Xiangtong Chemical Co., Ltd.
2020-09-25 SUCRALOSE
56038-13-2
US $36.00 / KG/Tin 10g 99% 10tons Hebei Lihe Biotechnology Co.,Ltd
2020-07-09 Sucralose
56038-13-2
US $40.00 / Kg/Bag 25KG 99% 500tons/month Hebei Yanxi Chemical Co., Ltd.

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