ChemicalBook CAS DataBase List tert-Butyl 2-bromo-2-methylpropanoate

tert-Butyl 2-bromo-2-methylpropanoate synthesis

4synthesis methods

Product Name:tert-Butyl 2-bromo-2-methylpropanoate
CAS Number:23877-12-5
Molecular formula:C8H15BrO2
Molecular Weight:223.11

2052-01-9 Synthesis

2052-01-9
259 suppliers
$10.00/1g

75-65-0 Synthesis

75-65-0
727 suppliers
$10.00/10ml

23877-12-5
324 suppliers
$7.00/5g

Yield:23877-12-5 125 g

Reaction Conditions:

with 4-methoxy-phenol;isobutene in dichloromethane at 41; for 5 h;Reflux;Reagent/catalyst;Temperature;

Steps:

5 Example 5

Into a three-necked flask having a capacity of 500 mL, 100 g of? -bromoisobutyric acid, 200 g of dichloromethane,1 g of p-hydroxyanisole,10 g of t-butanol, and then 5 g of CH-A type and 5 g of CHR-06 type cation exchange resin, respectively,The control temperature was 41 ° C,And do return. After the start of the reflux, 55 g of isobutene was fed to the reaction over 2 h,After 3h, the reaction solution was obtained. After the reaction, the cation exchange resin was filtered off,The reaction solution was adjusted to pH 6.5 with triethylamine and then subjected to atmospheric distillation at 80 ° C,And distilled under reduced pressure to obtain 125 g of t-butyl? -bromoisobutyrate in a purity of 99%.

References:

CN105601510,2016,A Location in patent:Paragraph 0032; 0033; 0034