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Trifluoromethanesulfonic acid

Description Chemical Properties Preparation Uses Reactions
Trifluoromethanesulfonic acid
Trifluoromethanesulfonic acid structure
Chemical Name:
Trifluoromethanesulfonic acid
TFMSA;FC-24;PFC-MS;Triflate;Trimsylate;Trimesylate;TRIFLIC ACID;Fluorad FC-24;TRIMESYLATE ACID;Trifluoromethanesulf
Molecular Formula:
Formula Weight:
MOL File:

Trifluoromethanesulfonic acid Properties

Melting point:
-40 °C
Boiling point:
162 °C(lit.)
1.696 g/mL at 25 °C(lit.)
vapor density 
5.2 (vs air)
vapor pressure 
8 mm Hg ( 25 °C)
refractive index 
n20/D 1.327(lit.)
Flash point:
storage temp. 
Miscible in H<sub>2</sub>O
-14(at 25℃)
Fuming Liquid
slightly brown
Specific Gravity
<1 (H2O)
Water Solubility 
Stable. Incompatible with acids, alkalis, metals.
CAS DataBase Reference
1493-13-6(CAS DataBase Reference)
NIST Chemistry Reference
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  C
Risk Statements  21/22-35-10
Safety Statements  26-36/37/39-45
RIDADR  UN 3265 8/PG 2
WGK Germany  2
Hazard Note  Corrosive/Hygroscopic
HazardClass  8
PackingGroup  II
HS Code  29049020
Toxicity LD50 orally in Rabbit: 1605 mg/kg LD50 dermal Rat > 2000 mg/kg
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H314 Causes severe skin burns and eye damage Skin corrosion/irritation Category 1A, B, C Danger P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger P280, P305+P351+P338, P310
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
H402 Harmful to aquatic life Hazardous to the aquatic environment, acute hazard Category 3
H412 Harmful to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 3 P273, P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P310 Immediately call a POISON CENTER or doctor/physician.
P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Trifluoromethanesulfonic acid price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 158534 Trifluoromethanesulfonic acid reagent grade, 98% 1493-13-6 50g $88.2 2018-11-13 Buy
Sigma-Aldrich 158534 Trifluoromethanesulfonic acid reagent grade, 98% 1493-13-6 10g $28.9 2018-11-13 Buy
TCI Chemical T0751 Trifluoromethanesulfonic Acid >98.0%(T) 1493-13-6 10g $27 2018-11-22 Buy
TCI Chemical T0751 Trifluoromethanesulfonic Acid >98.0%(T) 1493-13-6 25g $44 2018-11-22 Buy
Alfa Aesar A10173 Trifluoromethanesulfonic acid 98+% 1493-13-6 50g $73 2018-11-20 Buy

Trifluoromethanesulfonic acid Chemical Properties,Uses,Production


Trifluoromethanesulfonic acid, also known as triflic acid, TFMS, TFSA, HOTf or TfOH, is a sulfonic acid with the chemical formula CF3SO3H. It is often regarded as one of the strongest acids, and is one of a number of so-called "superacids". it is used in the manufacture of pharmaceuticals, agricultural chemicals and polymers. The anhydrous form is widely used in fine chemical synthesis. It is non-oxidizing, has a high thermal stability, and is resistance to both oxidation and reduction, which makes it one of the more useful compounds in the super acids class. In the pharma industry, it is used to make a number of drug classes, including nucleosides, antibiotics, steroids, proteins and glycosides. Triflic anhydride reacts readily with water and has an unfavorable toxicity profile.

Chemical Properties

Trifluoromethanesulfonic acid is a hygroscopic, colorless liquid at room temperature. It is soluble in polar solvents such as dimethylformamide (DMF), dimethyl sulfoxide (DMSO), acetonitrile, and dimethyl sulfone. Addition of triflic acid to polar solvents can be dangerously exothermic.
Trifluoromethanesulfonic acid is widely used especially as a catalyst and a precursor in organic chemistry. With an Ka = 8. 0 1014 (pKa ~ -15) mol/kg, HOTf qualifies as a superacid. Triflic acid owes many of its useful properties to its great thermal and chemical stability. Both the acid and its conjugate base CF3SO3-, known as triflate, resist oxidation/reduction reactions, whereas many strong acids are oxidizing, e. g. HClO4 and HNO3. The triflate anion is immune to attack by even strong nucleophiles. Because of its resistance to oxidation and reduction, triflic acid is a very useful and versatile reagent. Further recommending its use, triflic acid does not sulfonate substrates, which can be a problem with sulfuric acid, fluorosulfuric acid, and chlorosulfonic acid. Below is a prototypical sulfonation, which HOTf does not undergo: C6H6 + H2SO4 → C6H5(SO3H) + H2O.


Yellow-brown liquid. The boiling point is 167~170 ℃.The refractive index is 1.331.The relative density is 1.708.It is the strongest organic acids, easily soluble in water.Use carbon disulfide as raw material, with the reaction of iodine pentafluoride to produce trifluoromethyl disulfide.(CF3S) 2Hg was obtained when reacting with mercury; Then through oxidation of hydrogen oxide, trifluoromethanesulfonic acid is acquired.



Trifluoromethanesulfonic acid acts as a catalyst for esterification reactions and an acidic titrant in nonaqueous acid-base titration. It is useful in protonations due to the presence of conjugate base triflate is non nucleophilic. It serves as a deglycosylation agent for glycoproteins. In addition, it is a precursor and a catalyst in organic chemistry. It reacts with acyl halides to prepare mixed triflate anhydrides, which are strong acylating agents used in Friedel-Crafts reactions. It acts as a key starting material for the preparation of ethers and olefins by reacting with alcohols as well as to prepare trifluoromethanesulfonic anhydride by dehydration reaction.
Reaction in the presence of a nitrile provides a route to sterically hindered 2,4,6-trisubstituted pyrimidines
Catalyst used in the production of cocoa butter substitute from palm oil. This is a very similar reaction to what would be done if one wanted to create polymers using triflic acid in the synthesis. Other Friedel-Crafts type reactions using triflic acid include cracking of alkanes and alkylation of alkenes which are very important to the petroleum industry. These triflic acid derivative catalysts are very effective in isomerizing straight chain or slightly branched hydrocarbons that can increase the octane rating of a particular petroleum based fuel.

Chemical Properties

Clear very light yellow liquid


Acid catalyst for the industry, Intermediate for liquid crystals, Pharmaceuticals intermediates, Intermediate for organic synthesis. One of the strongest available monoprotic acids.


As a catalyst in Friedel-Crafts type acylation, alkylation and polymerization reactions; as a solvent for ESR; as a nonaqueous strong acid titrant; with trifluoroacetic acid, q.v., in solid-phase peptide synthesis.


ChEBI: A one-carbon compound that is methanesulfonic acid in which the hydrogens attached to the methyl carbon have been replaced by fluorines.

Safety Profile

A corrosive irritant to the skin, eyes, and mucous membranes. A strong acid. Violent reaction with acyl chlorides or aromatic hydrocarbons evolves toxic hydrogen chloride gas. When heated to decomposition it emits toxic fumes of Fand SOx. See also FLUORIDES.

Trifluoromethanesulfonic acid Preparation Products And Raw materials

Raw materials

Preparation Products

Trifluoromethanesulfonic acid Suppliers

Global( 366)Suppliers
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Dalian Richfortune Chemicals Co., Ltd
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86-411-84821380 China 362 57
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Mainchem Co., Ltd.
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Jiangsu Qingquan Chemical Co., Ltd.
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+86-571-87063838 CHINA 999 58
Tianjin Zhongxin Chemtech Co., Ltd.
022-66880086 CHINA 559 58

View Lastest Price from Trifluoromethanesulfonic acid manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-17 Trifluoromethanesulfonic acid
US $1.00 / KG 1G 98% 100KG career henan chemical co
2018-08-15 Trifluoromethanesulfonic acid
US $1.00 / KG 1KG 99% 200KG career henan chemical co

Trifluoromethanesulfonic acid Spectrum

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