ChemicalBook
Chinese Japanese Germany

Trifluoromethanesulfonic acid

Description Chemical Properties Preparation Uses Reactions
Trifluoromethanesulfonic acid
Trifluoromethanesulfonic acid
CAS No.
1493-13-6
Chemical Name:
Trifluoromethanesulfonic acid
Synonyms
TFMSA;FC-24;PFC-MS;Triflate;Trimsylate;Trimesylate;TRIFLIC ACID;Fluorad FC-24;TRIMESYLATE ACID;Trifluoromethanesulf
CBNumber:
CB7247316
Molecular Formula:
CHF3O3S
Formula Weight:
150.0770496
MOL File:
1493-13-6.mol

Trifluoromethanesulfonic acid Properties

Melting point:
-40 °C
Boiling point:
162 °C(lit.)
Density 
1.696 g/mL at 25 °C(lit.)
vapor density 
5.2 (vs air)
vapor pressure 
8 mm Hg ( 25 °C)
refractive index 
n20/D 1.327(lit.)
RTECS 
PB2771000
Flash point:
None
storage temp. 
−20°C
solubility 
Miscible in H<sub>2</sub>O
pka
-14(at 25℃)
form 
Fuming Liquid
color 
slightly brown
PH
<1 (H2O)
Water Solubility 
SOLUBLE
Sensitive 
Hygroscopic
Merck 
14,9676
BRN 
1812100
Stability:
Stable. Incompatible with acids, alkalis, metals.
InChIKey
ITMCEJHCFYSIIV-UHFFFAOYSA-N
CAS DataBase Reference
1493-13-6(CAS DataBase Reference)
NIST Chemistry Reference
CF3SO3H(1493-13-6)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  C
Risk Statements  21/22-35-10
Safety Statements  26-36/37/39-45
RIDADR  UN 3265 8/PG 2
WGK Germany  2
3-10
Hazard Note  Corrosive/Hygroscopic
TSCA  Yes
HazardClass  8
PackingGroup  II
HS Code  29049020
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H314 Causes severe skin burns and eye damage Skin corrosion/irritation Category 1A, B, C Danger P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger P280, P305+P351+P338, P310
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
H402 Harmful to aquatic life Hazardous to the aquatic environment, acute hazard Category 3
H412 Harmful to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 3 P273, P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P310 Immediately call a POISON CENTER or doctor/physician.
P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Trifluoromethanesulfonic acid price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 158534 Trifluoromethanesulfonic acid reagent grade, 98% 1493-13-6 10g $28.9 2018-11-13 Buy
Sigma-Aldrich 158534 Trifluoromethanesulfonic acid reagent grade, 98% 1493-13-6 50g $88.2 2018-11-13 Buy
TCI Chemical T0751 Trifluoromethanesulfonic Acid >98.0%(T) 1493-13-6 10g $27 2017-12-01 Buy
TCI Chemical T0751 Trifluoromethanesulfonic Acid >98.0%(T) 1493-13-6 25g $44 2017-12-01 Buy
Alfa Aesar A10173 Trifluoromethanesulfonic acid 98+% 1493-13-6 50g $73 2018-11-20 Buy

Trifluoromethanesulfonic acid Chemical Properties,Uses,Production

Description

Trifluoromethanesulfonic acid, also known as triflic acid, TFMS, TFSA, HOTf or TfOH, is a sulfonic acid with the chemical formula CF3SO3H. It is often regarded as one of the strongest acids, and is one of a number of so-called "superacids". it is used in the manufacture of pharmaceuticals, agricultural chemicals and polymers. The anhydrous form is widely used in fine chemical synthesis. It is non-oxidizing, has a high thermal stability, and is resistance to both oxidation and reduction, which makes it one of the more useful compounds in the super acids class. In the pharma industry, it is used to make a number of drug classes, including nucleosides, antibiotics, steroids, proteins and glycosides. Triflic anhydride reacts readily with water and has an unfavorable toxicity profile.

Chemical Properties

Trifluoromethanesulfonic acid is a hygroscopic, colorless liquid at room temperature. It is soluble in polar solvents such as dimethylformamide (DMF), dimethyl sulfoxide (DMSO), acetonitrile, and dimethyl sulfone. Addition of triflic acid to polar solvents can be dangerously exothermic.
Trifluoromethanesulfonic acid is widely used especially as a catalyst and a precursor in organic chemistry. With an Ka = 8. 0 1014 (pKa ~ -15) mol/kg, HOTf qualifies as a superacid. Triflic acid owes many of its useful properties to its great thermal and chemical stability. Both the acid and its conjugate base CF3SO3-, known as triflate, resist oxidation/reduction reactions, whereas many strong acids are oxidizing, e. g. HClO4 and HNO3. The triflate anion is immune to attack by even strong nucleophiles. Because of its resistance to oxidation and reduction, triflic acid is a very useful and versatile reagent. Further recommending its use, triflic acid does not sulfonate substrates, which can be a problem with sulfuric acid, fluorosulfuric acid, and chlorosulfonic acid. Below is a prototypical sulfonation, which HOTf does not undergo: C6H6 + H2SO4 → C6H5(SO3H) + H2O.

Preparation

Yellow-brown liquid. The boiling point is 167~170 ℃.The refractive index is 1.331.The relative density is 1.708.It is the strongest organic acids, easily soluble in water.Use carbon disulfide as raw material, with the reaction of iodine pentafluoride to produce trifluoromethyl disulfide.(CF3S) 2Hg was obtained when reacting with mercury; Then through oxidation of hydrogen oxide, trifluoromethanesulfonic acid is acquired.

Uses

Reactions

Trifluoromethanesulfonic acid acts as a catalyst for esterification reactions and an acidic titrant in nonaqueous acid-base titration. It is useful in protonations due to the presence of conjugate base triflate is non nucleophilic. It serves as a deglycosylation agent for glycoproteins. In addition, it is a precursor and a catalyst in organic chemistry. It reacts with acyl halides to prepare mixed triflate anhydrides, which are strong acylating agents used in Friedel-Crafts reactions. It acts as a key starting material for the preparation of ethers and olefins by reacting with alcohols as well as to prepare trifluoromethanesulfonic anhydride by dehydration reaction.
Reaction in the presence of a nitrile provides a route to sterically hindered 2,4,6-trisubstituted pyrimidines
Catalyst used in the production of cocoa butter substitute from palm oil. This is a very similar reaction to what would be done if one wanted to create polymers using triflic acid in the synthesis. Other Friedel-Crafts type reactions using triflic acid include cracking of alkanes and alkylation of alkenes which are very important to the petroleum industry. These triflic acid derivative catalysts are very effective in isomerizing straight chain or slightly branched hydrocarbons that can increase the octane rating of a particular petroleum based fuel.

Chemical Properties

Clear very light yellow liquid

Uses

Acid catalyst for the industry, Intermediate for liquid crystals, Pharmaceuticals intermediates, Intermediate for organic synthesis. One of the strongest available monoprotic acids.

Uses

As a catalyst in Friedel-Crafts type acylation, alkylation and polymerization reactions; as a solvent for ESR; as a nonaqueous strong acid titrant; with trifluoroacetic acid, q.v., in solid-phase peptide synthesis.

Definition

ChEBI: A one-carbon compound that is methanesulfonic acid in which the hydrogens attached to the methyl carbon have been replaced by fluorines.

Trifluoromethanesulfonic acid Preparation Products And Raw materials

Raw materials

Preparation Products


Trifluoromethanesulfonic acid Suppliers

Global( 343)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Dalian Richfortune Chemicals Co., Ltd
86-411-84820922, 84821539
86-411-84821380 sales@richfortunechem.com China 458 57
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19954 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
inquiry@dakenchem.com CHINA 22119 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20795 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555
+86-021-57951555 jack.li@time-chemicals.com CHINA 1374 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32764 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070;product@chemlin.com.cn
product@chemlin.com.cn CHINA 3015 60
Jiangsu Qingquan Chemical Co., Ltd.
+86-571-86589381/86589382/86589383
lyy@qqpharm.com sales1@qqpharm.com CHINA 137 55
Tianjin Zhongxin Chemtech Co., Ltd.
022-89880739
022-66880086 sales@tjzxchem.com CHINA 560 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 10011 58

View Lastest Price from Trifluoromethanesulfonic acid manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-17 Trifluoromethanesulfonic acid
1493-13-6
US $1.00 / KG 1G 98% 100KG
2018-08-15 Trifluoromethanesulfonic acid
1493-13-6
US $1.00 / KG 1KG 99% 200KG

1493-13-6(Trifluoromethanesulfonic acid)Related Search:


Copyright 2017 © ChemicalBook. All rights reserved