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18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
ChemicalBook CAS DataBase List Tebuconazole
107534-96-3

Tebuconazole synthesis

3synthesis methods
4H-1,2,4-Triazole-4-ethanol, α-[2-(4-chlorophenyl)ethyl]-α-(1,1-dimethylethyl)-

97821-63-1

Tebuconazole

107534-96-3

To a 250 mL three-necked flask was added 120 g of N,N-dimethylformamide, followed by 40 g of pentaconazole isomer, 2.0 g of potassium hydroxide, and 1.0 g of 3-bromomethyl-1-(4-chlorophenyl)-4,4-dimethyl-3-propanol.The reaction mixture was heated to 150 °C and maintained at this temperature for 4 hours. Sampling and analysis during the reaction showed that the purity of tebuconazole was 99.8% and the isomer content was 0.2%. Upon completion of the reaction, the target product tebuconazole was obtained by removing the solvent, followed by slurry treatment with water and toluene, and finally filtered to give 38.6 g of the target product tebuconazole in 96.5% yield and 98.5% product purity.

4H-1,2,4-Triazole-4-ethanol, α-[2-(4-chlorophenyl)ethyl]-α-(1,1-dimethylethyl)-

97821-63-1
1 suppliers
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Tebuconazole

107534-96-3
433 suppliers
$32.00/100mg

-

Yield:107534-96-3 96.5%

Reaction Conditions:

with 3-(bromomethyl)-1-(4-chlorophenyl)-4,4-dimethylpentan-3-ol;potassium hydroxide in N,N-dimethyl-formamide at 150; for 4 h;Reagent/catalyst;Solvent;Temperature;

Steps:

1

250 ml three-mouth bottle adding N, N - dimethyl formamide 120g, and add tebuconazole isomer 40g, potassium hydroxide 2.0g, 3 - bromomethyl -1 - (4 - chlorophenyl) - 4, 4 - dimethyl -3 - propanol 1.0g. The temperature to 150 °C reaction 4h. Sampling, the measured tebuconazole 99.8%, isomer 0.2%. After the desolvation, water and toluene after pulping, filtered to obtain product tebuconazole 38.6g, yield 96.5%, content of 98.5%.

References:

CN106699675,2017,A Location in patent:Paragraph 0024-0026

288-88-0 Synthesis
1,2,4-Triazole

288-88-0
827 suppliers
$10.00/5g

2-[2-(4-Chlorophenyl)ethyl]-2-(1,1-dimethylethyl)-oxirane

80443-63-6
112 suppliers
$28.00/5g

Tebuconazole

107534-96-3
433 suppliers
$32.00/100mg

References
41253-21-8 Synthesis
1,2,4-Triazolylsodium

41253-21-8
293 suppliers
$5.00/5g

1-(4-Chlorophenyl)-4,4-dimethyl-3-pentanone

66346-01-8
165 suppliers
$50.00/1g

Tebuconazole

107534-96-3
433 suppliers
$32.00/100mg

References

Tebuconazole Related Search:

Ethyl acetate Ethyl formate Ethanol Dimethyl sulfone Dimethyl sulfoxide N,N-Dimethylaniline N,N-Dimethylacetamide METCONAZOLE