tert-butyl 1-(3-broMophenyl)cyclopropylcarbaMate synthesis
- Product Name:tert-butyl 1-(3-broMophenyl)cyclopropylcarbaMate
- CAS Number:597563-17-2
- Molecular formula:C14H18BrNO2
- Molecular Weight:312.2
597563-15-0
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24424-99-5
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597563-17-2
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$240.00/250mg
Yield:597563-17-2 87.6%
Reaction Conditions:
with triethylamine in dichloromethane at 0 - 20; for 4 h;
Steps:
1 Step 1:
To a cooled (0°C) suspension of l-(3-bromophenyl)cyclopropan-l-amine hydrochloride (2.0 g, 8.05 mmol) in dry DCM (15 mL) were added di-tert-butyl dicarbonate (1.76 g, 8.05 mmol) and triethylamine (977.02 mg, 9.66 mmol). The reaction mixture was stirred at room temperature for 4h. Water (5 mL) was added, the organic phase was separated and washed with 5% aq. HC1, water, dried over sodium sulfate, filtered, and concentrated to give tert-butyl N-[l-(3-bromophenyl)cyclopropyl]carbamate (2.2 g, 7.05 mmol, 87.6% yield) as white solid.
References:
WO2020/221826,2020,A1 Location in patent:Page/Page column 154
124276-95-5
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75-65-0
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597563-17-2
26 suppliers
$240.00/250mg
24424-99-5
868 suppliers
$13.50/25G
546115-65-5
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$19.00/100mg
597563-17-2
26 suppliers
$240.00/250mg
6952-59-6
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$9.00/10g
597563-17-2
26 suppliers
$240.00/250mg